Modified Nucleic Acids / edited by Kazuhiko Nakatani, Yitzhak Tor.

Format:

Book

Contributor:

Nakatani, Kazuhiko, 1959- editor.

Tor, Yitzhak, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Nucleic acids and molecular biology 0933-1891 ; 31.

Nucleic Acids and Molecular Biology, 0933-1891 ; 31

Language:

English

Subjects (All):

Nucleic acids.

Cytology.

Biochemical engineering.

Nucleic Acid Chemistry.

Cell Biology.

Biochemical Engineering.

Local Subjects:

Nucleic Acid Chemistry.

Cell Biology.

Biochemical Engineering.

Physical Description:

1 online resource (X, 276 pages) : 162 illustrations, 62 illustrations in color.

Edition:

First edition 2016.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Contents:

Emissive 5-Substituted Uridine Analogues

Fluorescent purine nucleosides and their applications

Thiazole orange-tethered nucleic acids and ECHO probes for fluorometric detection of nucleic acids

Synthetic wavelength-shifting fluorescent probes of nucleic acids

DNA Assisted Multichromophore Assembly

Polymerase Synthesis of Base-Modified DNA

Photo-cross-linking Reaction in Nucleic Acids - Chemistry and Applications

Site-Directed Spin Labeling for EPR Studies of Nucleic Acids

Non-Covalent Modification of Double Stranded DNA at the Mismatch and Bulged Site

2',4'-Bridged Nucleic Acids for Targeting Double-Stranded DNA

Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-oxoguanine

Genetic alphabet expansion by unnatural base pair creation and its application to high affinity DNA aptamers.

Other Format:

Printed edition:

ISBN:

978-3-319-27111-8

9783319271118

Access Restriction:

Restricted for use by site license.