Mesenchymal Stromal Cells : Biology and Clinical Applications / edited by Peiman Hematti, Armand Keating.

Format:

Book

Contributor:

Hematti, Peiman, editor.

Keating, Armand, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Stem cell biology and regenerative medicine 2196-8985

Stem Cell Biology and Regenerative Medicine, 2196-8985

Language:

English

Subjects (All):

Stem cells.

Cytology.

Biotechnology.

Stem Cells.

Cell Biology.

Local Subjects:

Stem Cells.

Cell Biology.

Biotechnology.

Physical Description:

1 online resource (XXVI, 695 pages) : 61 illustrations, 40 illustrations in color.

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Humana, 2013.

System Details:

text file PDF

Summary:

Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues. .

Contents:

MSCs in regenerative medicine: A perspective

MSCs: Changing hypotheses, paradigms, and controversies on mechanisms of action in repairing tissues

MSCs: the need to rethink

Characterization of MSCs: From early studies to the present

MSCs as therapeutics

MSC niche for hematopoiesis

Immunomodulatory properties of MSCs

MSCs and the innate immune system: A balancing act

MSCs: paracrine effects

Cross-talk between MSCs and their environments

Human MSCs from bone marrow, umbilical cord blood and adipose tissue: all the same?

MSCs in solid tumors and hematological malignancies: from basic biology to therapeutic potential

MSC studies in large animal Models

Defining the potential of MSCs with a prenatal large animal Model

Bench-to-bedside development of MSC based therapies: A multidisciplinary approach

GMP production of MSCs

MSCs: The USA regulatory perspective

MSCs: Clinical applications and European regulatory aspects

Stem cell treatments around the world: boon or bane?

Safety issues in MSC therapy

In Vivo imaging of MSCs

National Heart, Lung, and Blood Institute support of cellular therapies regenerative medicine

MSC therapy of inborn errors

MSCs for enhancement of hematopoietic progenitor cell engraftment and poor graft function

MSCs for graft-versus-host disease

MSCs in paediatric hematopoietic stem cell transplantation

MSCs for ex vivo expansion of umbilical cord blood cells

MSCs for autoimmune disorders

MSCs for induction of solid organ allograft acceptance

MSCs for gastrointestinal disorders

MSCs for cardiac repair

MSCs for acute lung injury

MSCs for diabetes

MSCs for renal repair

MSCs for the treatment of stroke, spinal cord injury, and traumatic brain injury: From bench work to clinical trials

MSCs in reconstructive surgery

MSCs in orthopedic surgery

Adipose tissue derived MSCs: Moving to the clinic.

Other Format:

Printed edition:

ISBN:

978-1-4614-5711-4

9781461457114

Access Restriction:

Restricted for use by site license.