Experimental Metastasis: Modeling and Analysis / edited by Anastasia Malek.

Format:

Book

Contributor:

Malek, Anastasia, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Diagnosis, Laboratory.

Animal models in research.

Cell culture.

Cancer Research.

Laboratory Medicine.

Animal Models.

Cell Culture.

Local Subjects:

Cancer Research.

Laboratory Medicine.

Animal Models.

Cell Culture.

Physical Description:

1 online resource (VIII, 210 pages) : 71 illustrations, 32 illustrations in color

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

Metastatic dissemination remains a main cause for cancer related deaths. Investigation of the molecular mechanisms of the metastatic process presents an important area of cancer research and may provide clinical oncologists with new methods to prevent and manage cancer dissemination. Availability of adequate experimental models is an essential requirement of the productive investigation. Over the many years of cancer research, plenty of model systems (in vitro and in vivo) were created to reproduce certain steps or to estimate certain aspects of metastatic process. Currently right selection and correct application of the experimental models as well as analytic technique may present a challenge. This book provide with guideline information about experimental modelling and analysis of the metastatic process. The structure of the book reflects clinical aspects: pathway and area of the metastatic dissemination. Thus, first part of book is devoted to local, mainly via lymph system, spread of head and neck, breast and pancreatic cancers. Second part is about distant, via blood stream, dissemination into brain and lung (most often sites of metastatic lesion regardless the primary tumour issue). Third part includes chapter describing methods of modelling and study specific metastatic pathways: via portal vein system and through serous cavities. Any chapter is introduced by short review of clinical/biological aspects of the specific metastatic process, provides with description of relevant laboratory techniques, supplemented with representative illustrations and extended references list. Theoretic aspects of cancer dissemination and mathematic approaches to model metastatic spread of tumour are reviewed in the last chapter. Chapters of the book are written by leading specialists in certain areas of metastatic cancer research, therefore the book presents a comprehensive guide for researchers and may be helpful for clinical oncologists.

Contents:

Preface

Introduction

Head and neck cancer

Breast cancer invasion and metastasis

Mouse models of pancreatic cancer

Brain Metastasis

Lung metastasis

Liver Metastases

Malignant pleural effusion

Mathematic modeling of metastatic process. Index.

Other Format:

Printed edition:

ISBN:

978-94-007-7835-1

9789400778351

Access Restriction:

Restricted for use by site license.