Cancer Immunotherapy : Paradigms, Practice and Promise / edited by Tyler J. Curiel.

Format:

Book

Contributor:

Curiel, Tyler J., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Pharmacology.

Cancer Research.

Pharmacology/Toxicology.

Local Subjects:

Cancer Research.

Pharmacology/Toxicology.

Physical Description:

1 online resource (X, 486 pages)

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

This volume is a comprehensive discussion of the major factors affecting tumor immunology and a discussion of all major anti-cancer immunotherapeutic agents approved by the Food and Drug Administration of the United States and by European agencies. Many promising but unapproved agents in clinical trials are also discussed, as are key pre-clinical developments. The major challenges and intellectual issues facing investigators developing novel immunotherapeutics are discussed in detail as are conceptual developments influencing current and future treatment strategies. Each chapter begins by defining all relevant key terms and concepts and provides pertinent background information so that the text will be accessible to newcomers to the field as well as to the expert. This text book should provide an excellent reference resource for investigators in tumor immunology, life sciences students, drug developers designing novel anti-cancer immunotherapeutics, and to other individuals with some scientific training wishing to gain a better understanding of the field of tumor immunotherapy. Although the field is evolving rapidly, we have taken pains to ensure that information was as up to date as possible as the text went to press.

Contents:

Introduction

Historical Perspectives and Current Trends in Cancer Immunotherapy

T cell and Antigen-Presenting Cell Subsets in the Tumor Microenvironment

Adoptive T Cell Transfer

Dendritic Cell-Based Cancer Immunotherapy: Achievements and novel concepts

Peptide and Protein-based Cancer Vaccines

Antigen Targeting to Dendritic Cells for Cancer Immunotherapy

Cytokines in the Treatment of Cancer

Immune Co-signaling to Treat Cance

Managing Regulatory T cells

Myeloid-Derived Suppressor Cells in Cancer: Mechanisms and therapeutic perspectives

Antibodies as Cancer Immunotherapy

Targeted Toxins in Cancer Immunotherapy

Miscellaneous Approaches and Considerations: TLR agonists and other inflammatory agents, anti-chemokine agents, infectious agents, tumor stroma targeting, age and sex effects, and miscellaneous small molecules

Issues in Pre-clinical Models, Clinical Trial Design and Analytical Considerations in Developing and Evaluating Novel Cancer Immunotherapies

Monitoring Antigen-Specific Responses in Clinical Trials of Immunotherapy

Index.

Other Format:

Printed edition:

ISBN:

978-1-4614-4732-0

9781461447320

Access Restriction:

Restricted for use by site license.