Mitochondrial DNA, Mitochondria, Disease and Stem Cells / edited by Justin C. St. John.

Format:

Book

Contributor:

St. John, Justin C., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Stem cell biology and regenerative medicine 2196-8985

Stem Cell Biology and Regenerative Medicine, 2196-8985

Language:

English

Subjects (All):

Stem cells.

Cytology.

Cell physiology.

Stem Cells.

Cell Biology.

Cell Physiology.

Local Subjects:

Stem Cells.

Cell Biology.

Cell Physiology.

Physical Description:

1 online resource (X, 190 pages).

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

Totowa, NJ : Humana Press : Imprint: Humana, 2013.

System Details:

text file PDF

Summary:

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring's well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

Contents:

Clinical Approach to the Diagnosis of Mitochondrial Disease

Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease

Embryonic Stem Cells: A Signalling Perspective

From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) A Mitochondrial Odyssey

From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases

The Role of Mitochondrial DNA in Tumor Cells

Assisted Reproductive Technologies to Prevent the Transmission of mtDNA from one Generation to the Next.

Other Format:

Printed edition:

ISBN:

978-1-62703-101-1

9781627031011

Access Restriction:

Restricted for use by site license.