Adenosine : A Key Link between Metabolism and Brain Activity / edited by Susan Masino, Detlev Boison.

Format:

Book

Contributor:

Masino, Susan, editor.

Boison, Detlev, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Neurosciences.

Neurobiology.

Local Subjects:

Neurosciences.

Neurobiology.

Physical Description:

1 online resource (XVI, 680 pages)

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Contents:

Adenosine and metabolism - a brief historical note

Adenosine metabolism, adenosine kinase and evolution

Adenosine and energy metabolism - relationship to brain bioenergetics

Adenosine and autocrine metabolic regulation of neuronal activity

Physiologic and metabolic regulation of adenosine - mechanisms

The double edged sword: gaining adenosine at the expense of ATP. How to balance the books

Downstream pathways of adenosine

Astrocytic ATP release

Role of striatal A2A receptor subpopulations in neurological disorder

Sleep and adenosine: human studies

Adenosine and Other Purinergic Products in Circadian Timing

Adenosine in the immune system

The bioenergetics network of adenosine in hibernation, sleep and thermoregulation

Adenosine and stroke

The many roles of adenosine in traumatic brain injury

Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitutions after Spinal Cord Injury

Adenosine and pain

Symptomatic and neuroprotective effects of A2A receptor antagonists in Parkinson's Disease

Adenosine receptors and Alzheimer's Disease

Adenosine receptors in Huntington's Disease

Adenosine and Multiple Sclerosis

Adenosinergic perspectives on schizophrenia - Opportunity for an integrative synthesis

The role of adenosine in the ventral striatal circuits regulating behavioral activation and effort-related decision making: Importance for normal and pathological aspects of motivation

Adenosine and autism: Physiological symptoms and metabolic opportunities

Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes

Disruption of adenosine homeostasis in epilepsy and therapeutic adenosine augmentation

Ketogenic Diet and Epilepsy: The Role of Adenosine

Silk - a biocompatible and biodegradable biopolymer for therapeutic adenosine delivery

Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy.

Other Format:

Printed edition:

ISBN:

978-1-4614-3903-5

9781461439035

Access Restriction:

Restricted for use by site license.