Ten Years of Progress in GW/P Body Research / edited by Edward K. L. Chan, Marvin J. Fritzler.

Format:

Book

Contributor:

Chan, Edward K. L. (Edward Kar Leung), editor.

Fritzler, Marvin J., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Human genetics.

Cytology.

Biochemistry.

Human Genetics.

Cell Biology.

Biochemistry, general.

Local Subjects:

Human Genetics.

Cell Biology.

Biochemistry, general.

Physical Description:

1 online resource (XII, 276 pages)

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan's group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.

Contents:

Preface

The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology

The Discovery of GW Bodies

The Discovery and Analysis of P Bodies

Autoantibodies to Argonaute 2 (Su antigen)

GW/P Bodies and Autoimmune Disease

Function of GW182 and GW Bodies in siRNA and miRNA Pathways

Post-Transcriptional Stimulation of Gene Expression by MicroRNAs

Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue

The Role of GW182 Proteins in miRNA-mediated Gene Silencing

Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities

Deadenylation and P-bodies

Relationship of GW/P-bodies with Stress Granules

Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies

A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182

Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research

Index.

Other Format:

Printed edition:

ISBN:

978-1-4614-5107-5

9781461451075

Access Restriction:

Restricted for use by site license.