1 option
Microdialysis in Drug Development / edited by Markus Müller.
- Format:
- Book
- Series:
- Biomedical and Life Sciences (Springer-11642)
- AAPS advances in the pharmaceutical sciences series 2210-7371 ; 4.
- AAPS Advances in the Pharmaceutical Sciences Series, 2210-7371 ; 4
- Language:
- English
- Subjects (All):
- Pharmaceutical technology.
- Medicine.
- Pharmaceutical Sciences/Technology.
- Biomedicine, general.
- Local Subjects:
- Pharmaceutical Sciences/Technology.
- Biomedicine, general.
- Physical Description:
- 1 online resource (XII, 340 pages).
- Edition:
- First edition 2013.
- Contained In:
- Springer eBooks
- Place of Publication:
- New York, NY : Springer New York : Imprint: Springer, 2013.
- System Details:
- text file PDF
- Summary:
- In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
- Contents:
- Introduction to the Microdialysis Technology
- Recovery and Calibration Techniques: Toward Quantitative Microdialysis
- Analytical Considerations for Microdialysis Sampling
- Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective
- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations
- Microdialysis in Antibiotic Research
- Skin and Transdermal Drug Delivery: Advantages and Challenges
- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis
- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease
- Microdialysis in Pain Research
- Microdialysis in Ocular Drug Development
- Microdialysis in Metabolic Research
- High Molecular Weight Targets and Treatments Using Microdialysis
- Complementary Techniques - Positron Emission Tomography
- Open Flow Microperfusion: An Alternative Method to Microdialysis?
- Microdialysis in Internal Organs and Tumors.
- Other Format:
- Printed edition:
- ISBN:
- 978-1-4614-4815-0
- 9781461448150
- Access Restriction:
- Restricted for use by site license.
The Penn Libraries is committed to describing library materials using current, accurate, and responsible language. If you discover outdated or inaccurate language, please fill out this feedback form to report it and suggest alternative language.