Human Interphase Chromosomes : Biomedical Aspects / edited by Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov.

Format:

Book

Contributor:

I︠u︡rov, I︠u︡riĭ Borisovich, editor.

Vorsanova, Svetlana G., editor.

I︠U︡rov, Ivan I︠U︡rʹevich, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Human genetics.

Cytogenetics.

Cytology.

Human Genetics.

Cell Biology.

Local Subjects:

Human Genetics.

Cytogenetics.

Cell Biology.

Physical Description:

1 online resource (XVII, 216 pages)

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

The beginning of interphase cytogenetics can be attributed to significant advances in human molecular genetics and cytogenetics. Owing to experimental and theoretical research at the interface between cellular and molecular levels of chromosomal organization and function, high-resolution techniques for chromosomal analysis (molecular cytogenetic techniques) have become available. Molecular cytogenetics is a branch of biomedical sciences that explores chromosomes at molecular and single-cell resolutions at all stages of the cell cycle. It also comprises the techniques that operate with either the entire genome or specific DNA sequences to analyze genomic structural and functional variations at chromosomal level. In postgenomic era, molecular cytogenetics has appreciably transformed and has given rise to a new field of genomics, called cytogenomics. As a result, new opportunities have emerged for analysis of human interphase chromosomes in almost all cell types and states at unprecedented resolution. In Human Interphase Chromosomes, the editors have provided an overview of current developments in the study of human interphase chromosomes with a special attention to available molecular cytogenetictechnologies for basic and clinical chromosome research.

Contents:

Introduction. The view on human interphase chromosomes in postgenomic era

Interphase chromosome behavior in normal and diseased cells

Nuclear architecture, chromosome domains and genetic damage

Interphase chromosome of the human brain: the biological and clinical meaning of neural aneuploidy

Differentiating chromosome fragmentation and premature chromosome condensation

Chromosomes and nuclear organization in ICF Syndrome

Interphase cytogenetics at the earliest stages of human development

Organization of chromosomes in human sperm nucleus

Interphase chromosome-specific multicolor banding

Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei

Technological solutions in human interphase cytogenetics

Appendix: Molecular cytogenetics and interphase chromosomes on the internet

Index.

Other Format:

Printed edition:

ISBN:

978-1-4614-6558-4

9781461465584

Access Restriction:

Restricted for use by site license.