Pharmacoresistance in Epilepsy : From Genes and Molecules to Promising Therapies / edited by Luisa Rocha, Esper A. Cavalheiro.

Format:

Book

Contributor:

Rocha, Luisa, editor.

Cavalheiro, Esper A., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Pharmacology.

Pharmacology/Toxicology.

Local Subjects:

Neurosciences.

Neurology.

Pharmacology/Toxicology.

Physical Description:

1 online resource (XII, 329 pages)

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.

Contents:

Pharmacoresistance and Epilepsy

Genes involved in pharmacoresistant epilepsy

Pathological oscillations in the pharmacoresistant epileptic brain

Molecular mechanisms of pharmacoresistant epilepsy

Modifications in the seizures susceptibility by excitotoxic neuronal damage and its possible relationship with the pharmacoresistance

Intracellular pathways associated with neuronal survival and death in epilepsy

The role of JNK pathway in the process of excitotoxicity induced by epilepsy and neurodegeneration

Proteomics-based strategy to identify biomarkers and pharmacological targets in temporal lobe epilepsy

Abnormalities of GABA system and human pharmacoresistant epilepsy

Pharmacoresistant epilepsy and immune system

Contribution of the antiepileptic drug administration regime in the development and/or establishment of pharmacoresistant epilepsy

Experimental models to study pharmacoresistance in epilepsy

Resistance to epileptogenesis in the Neotropical rodent Proechimys

On the development of new antiepileptic drugs for the treatment of pharmacoresistant epilepsy - Different approaches to different hypothesis

Modulating P-glycoprotein regulation as a therapeutic strategy for pharmacoresistant epilepsy

Vagus Nerve Stimulation for Intractable Seizures

The role of neuromodulation in the treatment of refractory epilepsy

Transcranial magnetic stimulation and refractory partial epilepsy

Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity

Physical exercise as a strategy to reduce seizure susceptibility.

Other Format:

Printed edition:

ISBN:

978-1-4614-6464-8

9781461464648

Access Restriction:

Restricted for use by site license.