Structure and Physics of Viruses : An Integrated Textbook / edited by Mauricio G. Mateu.

Format:

Book

Contributor:

Mateu, Mauricio G., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Sub-cellular biochemistry 0306-0225 ; 68.

Subcellular Biochemistry, 0306-0225 ; 68

Language:

English

Subjects (All):

Medicine.

Proteins.

Virology.

Mechanics.

Biomedicine, general.

Protein Structure.

Classical Mechanics.

Local Subjects:

Biomedicine, general.

Protein Structure.

Virology.

Classical Mechanics.

Physical Description:

1 online resource (XIX, 728 pages) : 177 illustrations, 122 illustrations in color.

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

Structural Virology is today an all-important scientific discipline that permeates most other virological disciplines. The application of physical and physicochemical techniques has led to the determination of the high-resolution molecular structures of many viruses. The interplay of this approach with biochemical and biological approaches has allowed the elucidation of the structural basis of viral function in unprecedented detail. In addition, in the last years theoretical and experimental physicists have begun to tackle a fundamental physics-based approach to study different aspects of the architecture, self-assembly and material properties of virus particles. A new term, Physical Virology, has recently been coined to encompass these and related studies. This approach is beginning to merge with long-standing structural virology approaches to provide a renewed and richer view on viruses, as well as further advances in the fight against viral disease and the applications of viruses in biotechnology and nanotechnology. Structure and Physics of Viruses is an interdisciplinary textbook in which the rapidly expanding fields of structural and physical virology are dealt with in an integrated way. The authors have attempted to write a book basic enough to be useful to students, as well as advanced and current enough to be useful to senior scientists. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related sciences who share an interest or are actually working on viruses. It is aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. .

Contents:

Introduction: the structural basis of virus function

The basic architecture of viruses

Conventional electron microscopy, cryo-electron microscopy and cryo-electron tomography of viruses

X-ray crystallography of viruses.- Nuclear magnetic resonance spectroscopy to study virus structure

Fluorescence, circular dichroism and mass spectrometry as tools to study virus structure

Combined approaches to study virus structure

Atomic force microscopy of viruses

Optical tweezers to study viruses

Assembly of simple icosahedral viruses

Structure and assembly of complex viruses

Nucleic acid packaging in viruses

Virus maturation

Virus morphogenesis in the cell: methods and observations

Virus-receptor interactions and receptor-mediated virus entry into host cells

Entry of enveloped viruses into host cells: membrane fusion

Bacteriophage receptor recognition and nucleic acid transfer.- Mechanical properties of viruses

Theoretical studies on assembly, physical stability and dynamics of viruses

Antiviral agents: Structural basis of action and rational design

Design of novel vaccines based on virus-like particles or chimeric virions

Nanoscale science and technology with plant viruses and bacteriophages.

Other Format:

Printed edition:

ISBN:

978-94-007-6552-8

9789400765528

Access Restriction:

Restricted for use by site license.