Molecular Genetics of Inflammatory Bowel Disease / edited by Mauro D'Amato, John D Rioux.

Format:

Book

Contributor:

D'Amato, Mauro, editor.

Rioux, John D., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Human genetics.

Molecular biology.

Medicine.

Human Genetics.

Molecular Medicine.

Biomedicine, general.

Local Subjects:

Human Genetics.

Molecular Medicine.

Biomedicine, general.

Physical Description:

1 online resource (XIII, 343 pages) : 23 illustrations in color

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn's disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.

Contents:

Part 1: The Foundation of IBD Genetics, Human and Animal Studies

A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges

Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies

Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease

Part Two: The Genetic and Molecular Makeup of Inflammatory Bowel Disease

Complex Disease Genes and their Discovery

The Genetics of Crohn's Disease

Genetics of Ulcerative Colitis

Genetic Overlap between Inflammatory Bowel Disease and Other Diseases

Molecular Profiling of IBD Subtypes/Response to Therapy

Epigenetics of Inflammatory Bowel Disease

Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease

Nod1 and Nod2 and the Immune Response to Bacteria

The IL-23-Th17 Axis in Intestinal Inflammation

Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics

The Epithelial Barrier

Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli"

Cytokines in Inflammatory Bowel Disease

Part 4: Concluding Remarks and Future Perspectives

Towards Personalized Therapy in Inflammatory Bowel Disease

Index.

Other Format:

Printed edition:

ISBN:

978-1-4614-8256-7

9781461482567

Access Restriction:

Restricted for use by site license.