Mechanisms and Emerging Therapies in Tremor Disorders / edited by Giuliana Grimaldi, Mario Manto.

Format:

Book

Contributor:

Grimaldi, Giuliana, editor.

Manto, Mario, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Contemporary clinical neuroscience

Contemporary Clinical Neuroscience

Language:

English

Subjects (All):

Medicine.

Neurology.

Biomedicine, general.

Local Subjects:

Biomedicine, general.

Neurology.

Physical Description:

1 online resource (XVI, 492 pages).

Edition:

First edition 2013.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2013.

System Details:

text file PDF

Summary:

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.

Contents:

Part 1: Fundamental aspects

Definition of tremor

Membrane mechanisms of tremor

Rodent models of tremor

Advances in genetics of human tremor

Musculo-skeletal models of tremor

Part 2: The various forms of tremor in clinical practice: presentation and mechanism

Physiological tremor

Rest tremor

Postural tremors

Isometric tremor

Essential Tremor and Other Forms of Kinetic Tremor

Dystonic tremor

Orthostatic tremor

Vocal tremor

Update in Familial Cortical Myoclonic tremor with Epilepsy (FCMTE)

Post-traumatic tremor and Other Post-Traumatic Movement Disorders

Psychogenic tremor

Tremor in childhood

Part 3: Assessment of tremor: clinical, neurophysiological and neuroimaging aspects

Assessment of tremor: clinical and functional scales

Instrumentation: classical and emerging techniques

Signal processing

Diffusion imaging in tremor

The metabolic networks in Parkinson's disease

Part 4: Therapies of tremor

Pharmacological treatments of tremor

Thalamotomy

Brain Stimulation

Dopaminergic Influences on Rest and Action Tremors and Emerging Therapies for Tremor.

Other Format:

Printed edition:

ISBN:

978-1-4614-4027-7

9781461440277

Access Restriction:

Restricted for use by site license.