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Harnessing Nonlinear Magnetic Fields to Control Nanoparticle Delivery and Drug Release / Jessica F Liu.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Liu, Jessica F., author.
- Language:
- English
- Subjects (All):
- Bioengineering.
- Medicine.
- Biomedical engineering.
- Bioengineering--Penn dissertations.
- Penn dissertations--Bioengineering.
- Local Subjects:
- Bioengineering.
- Medicine.
- Biomedical engineering.
- Bioengineering--Penn dissertations.
- Penn dissertations--Bioengineering.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (257 pages)
- Contained In:
- Dissertations Abstracts International 81-04B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2019.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- The goal of drug delivery strategies is to increase the concentration of drug in target tissues such as tumors while minimizing delivery to off-target tissues. Despite recent advances in nanoparticle technology, many drug delivery strategies continue to rely on heterogeneous molecular and environmental markers for targeting, which limits specificity. Other strategies that use external stimuli such as light and ultrasound can damage nearby healthy tissues. Because the body is inherently nonmagnetic, magnetic fields and magnetic nanoparticles can be harnessed to develop bio-orthogonal systems for drug delivery. However, magnetic drug delivery systems that use alternating magnetic fields to trigger release from nanocarriers are limited by focusing of the alternating field, while magnetic drug delivery systems that use external static magnets to enhance nanocarrier accumulation at target sites are limited to use in surface regions. We have developed magnetic systems to address these problems for high-resolution spatially-targeted drug delivery and for improved nanoparticle penetration into tumor tissues. On short time scales, a static magnetic field can be used to gate the effect of alternating magnetic fields. Using this device, we are able to achieve spatially-targeted drug release with millimeter-scale resolution. A similar magnetic configuration comprising oppositely polarized static magnets can also be used to enhance nanocarrier penetration into deep tissues in vivo over longer time scales. Finally, to address the issue of nanocarrier purification, we have developed a microfluidic chip containing a cyclic magnetic micropump that rapidly processes small sample volumes with high purity and high retention.
- Notes:
- Source: Dissertations Abstracts International, Volume: 81-04, Section: B.
- Advisors: Tsourkas, Andrew; Issadore, David; Committee members: Brian Litt; Chris Murray; Jorge Alvarez.
- Department: Bioengineering.
- Ph.D. University of Pennsylvania 2019.
- Local Notes:
- School code: 0175
- ISBN:
- 9781687911223
- Access Restriction:
- Restricted for use by site license.
- This item is not available from ProQuest Dissertations & Theses.
- This item must not be sold to any third party vendors.
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