The Microbiome and the Brain / edited by David Perlmutter.

Format:

Book

Author/Creator:

Perlmutter, David, 1954-

Contributor:

Taylor & Francis eBooks.

Language:

English

Subjects (All):

Brain--Microbiology.

Human body--Microbiology.

Brain.

Microbiology.

Physical Description:

1 online resource (233 pages)

polychrome

Place of Publication:

Boca Raton, FL : CRC Press, [2020]

System Details:

text file

Biography/History:

Dr. Perlmutter is a Board-Certified Neurologist and Fellow of the American College of Nutrition who received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award. He has published extensively in peer-reviewed scientific journals including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition, and is a frequent lecturer at symposia sponsored by such medical institutions as Columbia University, Scripps Institute, New York University, and Harvard University. He serves as Associate Professor at the University of Miami Miller School of Medicine and serves on the editorial board of the Journal of Alzheimer's Disease, and The Journal of The American College of Nutrition. Dr. Perlmutter has been interviewed on many nationally syndicated television programs including 20/20, Larry King Live, CNN, Fox News, Fox and Friends, The Today Show, Oprah, The Dr.Oz Show and The CBS Early Show. He is the recipient of the Linus Pauling Award for his innovative approaches to neurological disorders and in addition was awarded the Denham Harmon Award for his pioneering work in the application of free radical science to clinical medicine. He is the recipient of the 2006 National Nutritional Foods Association Clinician of the Year Award and was awarded the Humanitarian of the Year award from the American College of Nutrition in, 2010. In 2015 Dr. Perlmutter was awarded both the Media Award from the American College of Nutrition and the Healthy Living Award from The Invisible Disabilities Association. Dr. Perlmutter is the author of nine books including the #1 New York Times Bestseller, Grain Brain, The Surprising Truth About Wheat, Carbs and Sugar - Your Brain's Silent Killers, now with over 1 million copies in print and published in 36 languages. His new book, Brain Wash, will be published in January, 2019.

Contents:

Cover; Half Title; Title Page; Copyright Page; Contents; Editor; List of Contributors; Introduction; Chapter 1: Assessing the Microbiome-Current and Future Technologies and Applications; Methods for Sequencing the Microbiome; 16S rRNA Sequencing; Shotgun Metagenomic Sequencing; Generating Data from Samples; Common Descriptive Analysis Techniques for Microbiome Data; Diversity Analysis; Relative Abundance Plots; Functional Genomics; Critical Appraisal of Microbiome Data; Simple, Community-Level Analyses-16S rRNA Sequencing; Detailed Metagenomic Analyses-Shotgun Metagenomic Sequencing

Bacterial Toxins Breaking the Gut and Blood-Brain BarriersThe Role of LPS in the Breakdown of the Blood-Brain Barrier and the Induction of Pathology in the CNS; Correlation of Intestinal Bacterial LPS Antibody with Occludin/Zonulin, S100B and Aquaporin 4; Association of Gram-Negative Bacterial Molecules (LPS, BCdT) with Alzheimer's Disease (AD); Circulating Antibodies against Bacterial Toxins May Become Pathogenic in the Context of BBB Breakdown; Conclusion; References; Chapter 4: The Microbiome-Its Role in Neuroinflammation: The Autism Spectrum Disorder Paradigm

Cross Communication between Brain and Gastrointestinal System: The Gut-Brain AxisCombined Gut and Blood-Brain Barriers Defects; ASD as a Prototypical Example of Gut-Brain Axis Dysfunction; CONCLUSION; References; Chapter 5: Nutrition and the Microbiome-Implications for Autism Spectrum Disorder; Introduction; ASD and Microbiota; ASD and Microbial Metabolites; Gastrointestinal Symptoms and ASD; Nutritional Challenges in Children with ASD; Influence of Diet on Microbiota Composition; Interventions Targeting the Microbiota in ASD to Manage Symptoms

Potential Role of Nutrition in the Microbiota-to-Brain Communication in ASDConclusions and Future Directions; References; Chapter 6: Alzheimer's Disease, the Microbiome, and 21st Century Medicine; Looking Forward; References; Chapter 7: Microbial Involvement in Alzheimer's Disease; Introduction: AD and Human Microbiome; Gut Microbiota and Alzheimer's; Impaired Microbiota and Alzheimer's; Human microbiome and risk factors of AD; Targeting Gut Microbiota for AD Interventions; Future Directions; Conclusions; References; Chapter 8: The Role of the Microbiome in Mood; INTRODUCTION

Notes:

Description based upon print version of record.

ReferencesChapter 2: The Microbiome - Role in Personalized Medicine; Introduction; The Microbiome and Its Impact on Cellular Modulation; The Uniqueness of the Microbiome-Brain Connection; Influence of the Microbiome on Immunometabolism; Taking it Personally: Dynamic Human Exposure and the Microbiome; Precision Personalized Medicine from the Microbiome; Notes; Chapter 3: Immune Response to Microbial Toxins in Inflammatory and Neurodegenerative Disorders; Introduction; The Role of Bacterial Toxins in Inflammatory and Autoimmune Disorders.

The Gut and its Microbiota

Electronic reproduction. London Available via World Wide Web.

Description based on online resource; title from digital title page (viewed on January 09, 2020).

Other Format:

Print version: Perlmutter, David The Microbiome and the Brain

ISBN:

9781351235693

1351235699

9781351235709

1351235702

9781351235679

1351235672

9781351235686

1351235680

Publisher Number:

99983060626

Access Restriction:

Restricted for use by site license.