Human genome epidemiology : building the evidence for using genetic information to improve health and prevent disease / edited by Muin J. Khoury ... [et al.].

Format:

Book

Contributor:

Khoury, Muin J.

Language:

English

Subjects (All):

Genetic disorders--Epidemiology.

Genetic disorders.

Medical genetics--Methodology.

Medical genetics.

Genomics.

Physical Description:

1 online resource (701 p.)

Edition:

2nd ed.

Place of Publication:

New York : Oxford University Press, 2010.

Language Note:

English

Summary:

This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice.

Contents:

Contents; Contributors; PART I: Fundamentals of Human Genome Epidemiology Revisited; 1. Human Genome Epidemiology: The Road Map Revisited; 2. Principles of Analysis of Germline Genetics; 3. The Public Health Genomics Enterprise; 4. Navigating the Evolving Knowledge of Human Genetic Variation in Health and Disease; PART II: Methods and Approaches for Data Collection, Analysis, and Integration; 5. The Global Emergence of Epidemiological Biobanks: Opportunities and Challenges; 6. Case-Control and Cohort Studies in the Age of Genome-wide Associations

7. The Emergence of Networks in Human Genome Epidemiology: Challenges and Opportunities8. Design and Analysis Issues in Genome-wide Association Studies; 9. The Challenge of Assessing Complex Gene-Environment and Gene-Gene Interactions; 10. STrengthening the REporting of Genetic Association Studies (STREGA)-an Extension of the STROBE Statement; 11. Integration of the Evidence on Gene-Disease Associations: Methods of HuGE Reviews; 12. Genome-wide Association Studies, Field Synopses, and the Development of the Knowledge Base on Genetic Variation and Human Diseases

PART III: Case Studies: Cumulative Assessment of the Role of Human Genome Variation in Specific Diseases13. Colorectal Cancer; 14. Childhood Leukemias; 15. Bladder Cancer; 16. Type 2 Diabetes; 17. Osteoporosis; 18. Preterm Birth; 19. Coronary Heart Disease; 20. Schizophrenia; PART IV: Applications of Epidemiologic Methods for Using Genetic Information in Medicine and Public Health; 21. Mendelian Randomization: The Contribution of Genetic Epidemiology to Elucidating Environmentally Modifiable Causes of Disease

22. Evaluation of Predictive Genetic Tests for Common Diseases: Bridging Epidemiological, Clinical, and Public Health Measures23. The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: Methods of the EGAPP Working Group; 24. Rapid, Evidence-based Reviews of Genetic Tests; 25. Role of Social and Behavioral Research in Assessing the Utility of Genetic Information; 26. Assessing the Evidence for Clinical Utility in Newborn Screening; 27. The Role of Epidemiology in Assessing the Potential Clinical Impact of Pharmacogenomics; 28. The Human Epigenome and Cancer

29. The Use of Family History in Public Health Practice: The Epidemiologic ViewPART V: Case Studies: Assessing the Use of Genetic Information in Practice for Specific Diseases; 30. Cytochrome P450 Testing in the Treatment of Depression; 31. A Rapid-ACCE Review of CYP2C9 and VKORC1 Allele Testing to Inform Warfarin Dosing in Adults at Elevated Risk for Thrombotic Events to Avoid Serious Bleeding; 32. Hereditary Hemochromatosis: Population Screening for Gene Mutations; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Z

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

1-282-54452-7

9786612544521

0-19-974934-5

OCLC:

646051709