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Human genome epidemiology : building the evidence for using genetic information to improve health and prevent disease / edited by Muin J. Khoury ... [et al.].
- Format:
- Book
- Author/Creator:
- Khoury, Muin, Editor.
- Language:
- English
- Subjects (All):
- Genetic disorders--Epidemiology.
- Genetic disorders.
- Medical genetics--Methodology.
- Medical genetics.
- Genomics.
- Genetic screening.
- Human genome.
- Genetics, Medical--methods.
- Genetic Diseases, Inborn--epidemiology.
- Genetic Predisposition to Disease--epidemiology.
- Genetic Testing.
- Genome, Human.
- Medical Subjects:
- Genetics, Medical--methods.
- Genetic Diseases, Inborn--epidemiology.
- Genetic Predisposition to Disease--epidemiology.
- Genetic Testing.
- Genome, Human.
- Genomics.
- Physical Description:
- 1 online resource (xxiii, 676 pages) : illustrations
- Edition:
- 2nd ed.
- Other Title:
- Building the evidence for using genetic information to improve health and prevent disease
- Place of Publication:
- Oxford University Press 2010
- Language Note:
- English
- Summary:
- This text describes the role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It provides a foundation that should help researchers, policy makers and practitioners integrate genomics into medical and public health practice.
- Contents:
- Human genome epidemiology: the road map revisited
- Principles of analysis of germline genetics
- The public health genomics enterprise
- Navigating the evolving knowledge of human genetic variation in health and disease
- The global emergence of epidemiological biobanks: opportunities and challenges
- Case-control and cohort studies in the age of genome-wide associations
- The emergence of networks in human genome epidemiology: challenges and opportunities
- Design and analysis issues in genome-wide association studies
- The challenge of assessing complex gene-environment and gene-gene interactions
- STrengthening the REporting of genetic association studies (STREGA)-an extension of the STROBE statement
- Integration of the evidence on gene-disease associations: methods of HuGE reviews
- Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
- Colorectal cancer
- Childhood leukemias
- Bladder cancer
- Type 2 diabetes
- Osteoporosis
- Preterm birth
- Coronary heart disease
- Schizophrenia
- Mendelian randomization: the contribution of genetic epidemiology to elucidating environmentally modifiable causes of disease
- Evaluation of predictive genetic tests for common diseases: bridging epidemiological, clinical, and public health measures
- The evaluation of genomic applications in practice and prevention (EGAPP) initiative: methods of the EGAPP working group
- Rapid, evidence-based reviews of genetic tests
- Role of social and behavioral research in assessing the utility of genetic information
- Assessing the evidence for clinical utility in newborn screening
- The role of epidemiology in assessing the potential clinical impact of pharmacogenomics
- The human epigenome and cancer
- The use of family history in public health practice: the epidemiologic view
- Cytochrome P450 testing in the treatment of depression
- A rapid-ACCE review of CYP2CP and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding
- Hereditary hemochromatosis: population screening for gene mutations.
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- Description based on print version record.
- Description based on publisher supplied metadata and other sources.
- ISBN:
- 1-282-54452-7
- 9786612544521
- 0-19-974934-5
- OCLC:
- 646051709
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