Hemoglobin : insights into protein structure, function, and evolution / Jay F. Storz.

Format:

Book

Author/Creator:

Storz, Jay F., author.

Series:

Oxford scholarship online.

Oxford scholarship online

Language:

English

Subjects (All):

Hemoglobin.

Physical Description:

1 online resource (258 pages)

Edition:

First edition.

Place of Publication:

Oxford University Press 2019

Summary:

The primary aim of this book is to provide a synthesis of our current understanding of hemoglobin function and evolution, and to illustrate how research on one particular family of proteins has provided general insights into mechanisms of protein evolution and biochemical adaptation. In doing so, it will also promote an appreciation of how mechanistic insights into protein function can enrich our understanding of how evolution works. Reciprocally, it highlights how approaches in evolutionary genetics (such as phylogenetic comparative methods and ancestral sequence reconstruction) can be brought to bear on questions about the functional evolution of proteins. This treatise on the functional evolution of hemoglobin illustrates how research on a single, well-chosen model system can enhance our investigative acuity and bring key conceptual questions into especially sharp focus.

Contents:

Hemoglobin: Insights into Protein Structure, Function, and Evolution Plates Chapter 1: Principles of protein structure Chapter 2: A study in scarlet: The role of hemoglobin in blood gas transport Chapter 3: Allosteric theory Chapter 4: Hemoglobin structure and allosteric mechanism Chapter 5: Evolution of the vertebrate globin gene family Chapter 6: Gene duplication and hemoglobin isoform differentiation Chapter 7: The evolution of novel hemoglobin functions and physiological innovation Chapter 8: Biochemical adaptation to environmental hypoxia Chapter 9: Darwin's molecule: Evolutionary insights into mechanisms of biochemical adaptation and protein evolution

Notes:

This edition previously issued in print: 2018.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

0-19-184792-5

0-19-253876-4