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Mass Spectrometry: An Ideal Method for Rna Modification Analysis / Samuel Wein.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Wein, Samuel, author.
- Language:
- English
- Subjects (All):
- Biochemistry.
- Bioinformatics.
- Biochemistry and molecular biophysics--Penn dissertations.
- Penn dissertations--Biochemistry and molecular biophysics.
- Local Subjects:
- Biochemistry.
- Bioinformatics.
- Biochemistry and molecular biophysics--Penn dissertations.
- Penn dissertations--Biochemistry and molecular biophysics.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (101 pages)
- Contained In:
- Dissertations Abstracts International 81-02B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2019.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- Currently there is no good way to measure and find the exact location of multiple RNA modifications. Existing technology can effectively find single varieties of modifications, but cannot identify co-occurrence. As the field of proteomics has shown, mass spectrometry is a powerful and versatile technique assessing broad ranges of chemical modifications in the context of the cellular environment. In this project I used our expertise in proteomics to build a mass spectrometry based platform for identifying RNA modifications. I have since set up both software and analytical platforms querying RNA modifications, and used this platform to survey human tRNA samples and identify what modifications there are, and where they occur.
- Notes:
- Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
- Advisors: Garcia, Benjamin A.; Committee members: Kim Sharp; David Speicher; Jeremy Wilusz; John Karanicolas.
- Department: Biochemistry and Molecular Biophysics.
- Ph.D. University of Pennsylvania 2019.
- Local Notes:
- School code: 0175
- ISBN:
- 9781085568968
- Access Restriction:
- Restricted for use by site license.
- This item must not be sold to any third party vendors.
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