Immunotherapy of Hepatocellular Carcinoma / edited by Tim F. Greten.

Format:

Book

Contributor:

F. Greten, Tim, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Medicine.

Biomedicine, general.

Local Subjects:

Biomedicine, general.

Physical Description:

1 online resource (X, 167 pages) : 19 illustrations, 15 illustrations in color

Edition:

First edition 2017.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

In this book we provide insights into liver - cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical "inflammation-induced" cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. .

Contents:

Preface

Introduction

Vaccine approaches

Spontaneous Immune responses to ablative therapies

Antigen-specific T cell responses. Immune checkpoint inhibitors

NASH and HCC

Cytokine activated killer cells

Sorafenib combination therapy

Glypican 3

Suppressor cells

Cytokines in HCC pathogenesis and treatment

Index.

Other Format:

Printed edition:

ISBN:

978-3-319-64958-0

9783319649580

Access Restriction:

Restricted for use by site license.