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IgM and Its Receptors and Binding Proteins / edited by Hiromi Kubagawa, Peter D. Burrows.
Holman Biotech Commons QR1 .E6 v.253 (2001)-v.363,v.367-v.371
Available
Veterinary: Atwood Library (Campus) QR181 O75 2000
Available
LIBRA v.40 (1967)-v.113 (1984), v.115 (1985)-v.203 (1995), v.205 (1996)-v.252 (2000)
Available from offsite location
Levy Dental Medicine Library - Stacks QR1 .E6 215,271
Mixed Availability
Veterinary: du Pont Library (New Bolton) QR1 .E6 280
Mixed Availability
Veterinary: Atwood Library (Campus) QR1 .E6 271
Mixed Availability
- Format:
- Book
- Series:
- Biomedical and Life Sciences (Springer-11642)
- Current topics in microbiology and immunology 0070-217X ; 408.
- Current Topics in Microbiology and Immunology, 0070-217X ; 408
- Language:
- English
- Subjects (All):
- Immunology.
- Infectious diseases.
- Rheumatology.
- Infectious Diseases.
- Local Subjects:
- Immunology.
- Infectious Diseases.
- Rheumatology.
- Physical Description:
- 1 online resource (IX, 117 pages) : 30 illustrations, 15 illustrations in color.
- Edition:
- First edition 2017.
- Contained In:
- Springer eBooks
- Place of Publication:
- Cham : Springer International Publishing : Imprint: Springer, 2017.
- System Details:
- text file PDF
- Summary:
- This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fcα/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.
- Contents:
- The appearance and diversification of receptors for IgM during vertebrate evolution.
- Authentic IgM Fc Receptor (FcμR)
- FCRLA - A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells
- Specific IgM and regulation of antibody responses
- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.
- Other Format:
- Printed edition:
- ISBN:
- 978-3-319-64526-1
- 9783319645261
- Access Restriction:
- Restricted for use by site license.
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