Mechanisms of Vascular Defects in Diabetes Mellitus / edited by C.C. Kartha, Surya Ramachandran, Radhakrishna M. Pillai.

Format:

Book

Contributor:

Kartha, C. Chandrasekharan, editor.

Ramachandran, Surya, editor.

Pillai, M. Radhakrishna (Madhavan Radhakrishna), 1960- editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Advances in biochemistry in health and disease ; 17.

Advances in Biochemistry in Health and Disease ; 17

Language:

English

Subjects (All):

Cytology.

Diabetes.

Cell Biology.

Local Subjects:

Cell Biology.

Diabetes.

Physical Description:

1 online resource (XVIII, 579 pages) : 75 illustrations, 54 illustrations in color.

Edition:

First edition 2017.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This book comprising 24 chapters is devoted to the mechanisms for the pathogenesis of the spectrum of vascular diseases in diabetes. Cellular events and molecular pathways that regulate the structure and function of both small and large arteries, the dysregulation in these vessels caused by hyperglycemia, oxidative stress, metabolic and haemostatic derangements secondary to diabetes, are discussed. Mechanisms of vascular remodelling and rupture of atherosclerotic plaques in diabetes are also covered. Several of the reviews also discuss therapeutic targets and drugs employed to reduce endothelial dysfunction and vascular inflammation in diabetes. All articles are authored by experts in their respective research fields. This compendium will be of interest to both basic scientists and clinicians in the pursuit of unravelling the molecular basis of vascular diseases and also to those who seek to identify targets for therapy of vascular complications of diabetes.

Contents:

Section 1 Introduction

The Global Burden Of Diabetes And Its Vascular Complications

SECTION 2 Pathogenesis

Genetic Basis For Increased Risk For Vascular Diseases In Diabetes

Vascular Remodelling In Diabetes Mellitus

Pathogenesis Of The Plaque Vulnerability In Diabetes Mellitus

Endothelial Dysfunction In Diabetes

Smooth Muscle Cells In Diabetes Mellitus

Monocytes Factors In Pathogenesis Of Vascular Lesions In Diabetes

Endothelial Progenitor Cell Dysfunction In The Pathogenesis Of Vascular Complications Of Diabetes

Pathogenetic mechanisms in diabetic retinopathy: from molecules to cells to tissues

Perspectives on the vascular pathogenesis of diabetic neuropathy

SECTION 3 Molecular mechanisms

The Renin - Angiotensin System And Diabetes

Adipokines And Vascular Disease In Diabetes

G-Proteins In Vascular Complications Of Diabetes

Histone Deacetylases In Vascular Pathophysiology: Regulation By Vasoactive Peptides And Growth Factors

Role of non-coding RNAs in vascular complications of diabetes mellitus

SECTION 4 Hemostatic Factors

Diabetes As A Prothrombotic State

Mechanisms Of Hypercoagulation And Aberrant Clot Lyses In Type 2 Diabetes

Platelet Dysfunction In Type-2 Diabetes Mellitus

SECTION 5 Metabolic Factors

Advanced Glycation End Products In Diabetic Complications

Atherogenicdyslipoproteinemia In Type 2 Diabetes Mellitus

Vascular Remodeling: Homocysteine And Diabetes

SECTION 6 Pharmacological Therapies

Mechanisms Of Action Of Drugs For Treating Endothelial Dysfunction In Diabetes Mellitus

Beneficial Effects Of Inorganic Nitrate/Nitrite On Vascular Function And Blood Pressure In Diabetes

Myeloperoxidase (MPO): Do We Need Inhibitors?.

Other Format:

Printed edition:

ISBN:

978-3-319-60324-7

9783319603247

Access Restriction:

Restricted for use by site license.