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Actin Polymerization in Apicomplexan : A Structural, Functional and Evolutionary Analysis / edited by Avinash Kale.
SpringerLink Books Biomedical and Life Sciences 2019 Available online
SpringerLink Books Biomedical and Life Sciences 2019- Format:
- Book
- Series:
- Biomedical and Life Sciences (Springer-11642)
- Language:
- English
- Subjects (All):
- Parasitology.
- Biomechanics.
- Proteins.
- Bioinformatics.
- Protein Science.
- Protein Structure.
- Local Subjects:
- Parasitology.
- Biomechanics.
- Protein Science.
- Protein Structure.
- Bioinformatics.
- Physical Description:
- 1 online resource (XI, 101 pages) : 11 illustrations in color
- Edition:
- First edition 2019.
- Contained In:
- Springer eBooks
- Place of Publication:
- Singapore : Springer Singapore : Imprint: Springer, 2019.
- System Details:
- text file PDF
- Summary:
- This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
- Contents:
- Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles
- Chapter 2. Introduction: Gliding Motility- The model and the mechanism
- Chapter 3. Actin: The central ubiquitous player in the phenomenon
- Chapter 4. Formin: The multidomain elongator of polymer
- Chapter 5. Profilin: The associates of Formin
- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis
- Chapter 7. Cyclase associated protein (CAP): The silent worker
- Chapter 8. Capping Protein (CP): The formin competitor
- Chapter 9. Coronin: An Overview
- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators
- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan.
- Other Format:
- Printed edition:
- ISBN:
- 978-981-13-7450-0
- 9789811374500
- Access Restriction:
- Restricted for use by site license.
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