Marburg- and Ebolaviruses : From Ecosystems to Molecules / edited by Elke Mühlberger, Lisa L. Hensley, Jonathan S. Towner.

Format:

Book

Contributor:

Mühlberger, Elke, editor.

Hensley, Lisa L., editor.

Towner, Jonathan S., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Current topics in microbiology and immunology 0070-217X ; 411.

Current Topics in Microbiology and Immunology, 0070-217X ; 411

Language:

English

Subjects (All):

Virology.

Infectious diseases.

Epidemiology.

Infectious Diseases.

Local Subjects:

Virology.

Infectious Diseases.

Epidemiology.

Physical Description:

1 online resource (X, 460 pages).

Edition:

First edition 2017.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2017.

System Details:

text file PDF

Summary:

This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy. For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure. Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.

Contents:

Filovirus Research: How it began

Ecology of Filoviruses

West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis

Clinical Management of Ebola Virus Disease Patients in Low Resource Settings

Clinical Management of Patients with Ebola Virus Disease in High Resource Settings

Ebola Virus Disease in Humans: Pathophysiology and Immunity

Nonhuman Primate Models of Ebola Virus Disease

Small Animal Models for Studying Filovirus Pathogenesis

Accelerating Vaccine Development during the West African Ebola Virus Disease Outbreak

Therapeutics against Filovirus Infection

Filovirus Strategies to Escape Antiviral Responses

Mechanisms of Filovirus Entry

Inside the Cell: Assembly of Filoviruses

Filovirus Structural Biology: The Molecules in the Machine

Reverse Genetics of Filoviruses

Guide to the Correct Use of Filoviral Nomenclature.

Other Format:

Printed edition:

ISBN:

978-3-319-68948-7

9783319689487

Access Restriction:

Restricted for use by site license.