Antibacterial Drug Discovery to Combat MDR : Natural Compounds, Nanotechnology and Novel Synthetic Sources / edited by Iqbal Ahmad, Shamim Ahmad, Kendra P. Rumbaugh.

Format:

Book

Contributor:

Aḥmad, Iqbāl, editor.

Ahmad, Shamim (Professor of microbiology), editor.

Rumbaugh, Kendra P., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Medical microbiology.

Pharmacology.

Infectious diseases.

Bacteriology.

Nanotechnology.

Medical Microbiology.

Pharmacology/Toxicology.

Infectious Diseases.

Local Subjects:

Medical Microbiology.

Pharmacology/Toxicology.

Infectious Diseases.

Bacteriology.

Nanotechnology.

Physical Description:

1 online resource (XII, 680 pages) : 63 illustrations, 31 illustrations in color

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Contents:

Antibacterial drug discovery: perspective insights

Section A: The Challenge of Antibiotic Resistance and Tolerance

Problematic Groups of Multidrug Resistant Bacteria and their Resistance Mechanisms

Emergence and spread of multi-drug resistance in ocular bacterial pathogens: A current update

Antibiotic resistance in Campylobacter jejuni: mechanism, status and public health significance

Mechanisms of biofilm development, antibiotic resistance and tolerance and their role in persistent infections

Developing in vivo infection models with MDR pathogens for evaluating compound efficacy

Section B. New antibiotic drug discovery approaches and progress

Endophytes: a hidden treasure of novel antimicrobial metabolites

Alternative therapies to antibiotics to combat drug-resistant bacterial pathogens

In silico molecular modeling: key technologies in the drug discovery process to combat multidrug resistance

Computational approaches for antibacterial drug discovery

Efflux pump inhibitors and their role in the reversal of drug resistance

Medicinal plants as a reservoir of new structures for anti-infective compounds

Essential oils: Potential application in disease management

Exploration of soil resistome through a metagenomic approach

Actinomycetes as a continued source of new antibacterial leads

Are Ancient Remedies the New Answer to Fighting Infections?

Section C. Alternative antibiotic resistance treatment strategies

Pre and probiotics: Using functional foods in the fight against microbial resistance to antibiotics

Combination of drugs: an effective approach for enhancing the efficacy of antibiotics to combat drug resistance

Targeted delivery of antibiotics using microparticles to combat multi-drug-resistant tuberculosis

Practical applications of bacteriophage therapy: biofilms to bedside

Inhibition of Quorum sensing; prospects in disease control

Approaches for disrupting tissue-associated biofilms

Nanomedicine and nanoemulsion in increasing the availability of antibiotics

Nanoparticles as new emerging antibacterials: potential and limitation

Nanomaterials as a novel class of anti-infective agents that attenuate bacterial quorum sensing

Nanoparticle-based drug delivery systems: promising approaches against bacterial infections

Green synthesis of metal nanoparticles: characterization and their antibacterial efficacy.

Other Format:

Printed edition:

ISBN:

978-981-13-9871-1

9789811398711

Access Restriction:

Restricted for use by site license.