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Co-signal Molecules in T Cell Activation : Immune Regulation in Health and Disease / edited by Miyuki Azuma, Hideo Yagita.
LIBRA Per. v.1 (1967)-v.111 (1979) v.112 (1980)-v.267 (1990), v.269 (1990)-v.330 (1993), v.332 (1993)-v.363 (1995), v.365 (1994)-v.367 (1995), v.369 (1995)-v.370 (1994), v.371B (1995), v.372 (1995)-v.373 (1995), v.375 (1995)-v.401 (1996), v.403 (1996), v.406 (1997), v.408 (1997)-v.482 (2000)-v.483 (2000)
Available from offsite location
Holman Biotech Commons R850.A1 A39 v.484 (2001)-v.506 Pt.A (2002), v.506 Pt.B (2002), v.507 (2002)-v.538 (2003), v.539 Pt.A-B (2003), v.540 (2003)-v.554 (2004), v.557 (2006)-v.561 (2005), v.563 (2005)-v.585 (2006),v.587 (2006)-v.600 (2007), v.601 (2007)-v.611 v.612-v.664,v.669-v.681,v.682-v.687,v.689-v.694,v.696-v.698,v.700-v.730,v.732-v.740,v.742-v.751,v.754-v.758,v.760,v.762-v.765,v.767-v.771,v.774-v.780,v.782-v.788,v.790,v.942,v.946,v.954,v.961,v.970,v.984-v.986,v.990-v.992
Mixed Availability
- Format:
- Book
- Series:
- Biomedical and Life Sciences (Springer-11642)
- Advances in experimental medicine and biology 0065-2598 ; 1189.
- Advances in Experimental Medicine and Biology, 0065-2598 ; 1189
- Language:
- English
- Subjects (All):
- Immunology.
- Cancer--Research.
- Cancer.
- Neurology.
- Oncology.
- Cancer Research.
- Local Subjects:
- Immunology.
- Cancer Research.
- Neurology.
- Oncology.
- Physical Description:
- 1 online resource (VI, 326 pages) : 22 illustrations, 21 illustrations in color.
- Edition:
- First edition 2019.
- Contained In:
- Springer eBooks
- Place of Publication:
- Singapore : Springer Singapore : Imprint: Springer, 2019.
- System Details:
- text file PDF
- Summary:
- This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science. .
- Contents:
- Part I: Basic Understanding of Co-signal Molecules in T cell activation
- Chapter 1 Co-signal molecules in T cell activation
- Chapter 2 The CD28-B7 family of co-signaling molecules
- Chapter 3 The TNF YNFR family of co-signal molecules
- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors
- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation
- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation
- Chapter 7 Control of regulatory T cells by co-signal molecules
- Part II: Co-signal Molecules in Health and Disease
- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity
- Chapter 9 Co-signaling molecules in neurological diseases
- Chapter 10 Costimulation blockade in transplantation
- Chapter 11 Immunotherapy targeting co-signal molecules. .
- Other Format:
- Printed edition:
- ISBN:
- 978-981-32-9717-3
- 9789813297173
- Access Restriction:
- Restricted for use by site license.
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