Osteosarcopenia: Bone, Muscle and Fat Interactions / edited by Gustavo Duque.

Format:

Book

Contributor:

Duque, Gustavo, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Aging.

Developmental biology.

Geriatrics.

Endocrinology.

Biogerontology.

Geriatrics/Gerontology.

Local Subjects:

Biogerontology.

Geriatrics/Gerontology.

Endocrinology.

Physical Description:

1 online resource (XVI, 383 pages) : 42 illustrations, 28 illustrations in color

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions - including the role of local bone and muscle fat - followed by comprehensive reviews on myokines (id est myostatin), osteokines (id est osteocalcin) and adipokines (id est interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (id est estrogens, androgens), and calciotropic hormones (id est parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Contents:

Dedication

Foreword

Preface

Acknowledgements

PART I Biology of Muscle and Bone

Muscle and Bone Biology

Mesenchymal stem cells as regulators of bone, muscle, and fat formation

Age-related changes in muscle and bone

Cross-talk between muscle and bone

Role of connexins and pannexins in bone and muscle mass and function

Osteosarcopenia as a Lipotoxic Disease

The endocrine actions of undercarboxylated osteocalcin in skeletal muscle: effects and mechanisms

Sex steroid hormones and osteosarcopenia

Calciotropic hormones and osteosarcopenia

Genetics of Osteosarcopenia

PART II Clinical Characteristics

Diagnosis of Osteosarcopenia - clinical

Diagnosis of Osteosarcopenia - Imaging

Diagnosis of osteosarcopenia - Biochemistry and pathology

Osteosarcopenic obesity

Non-pharmacological interventions for osteosarcopenia

The Falls and Fractures Clinic - An integrated model of care for osteosarcopenic patients

Index.

Other Format:

Printed edition:

ISBN:

978-3-030-25890-0

9783030258900

Access Restriction:

Restricted for use by site license.