SIRT6 Activities in DNA Damage Repair and Premature Aging : Functions of SIRT6 / by Shrestha Ghosh.

Format:

Book

Author/Creator:

Ghosh, Shrestha, author.

Contributor:

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Springer Theses, Recognizing Outstanding Ph.D. Research,. 2190-5053

Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053

Language:

English

Subjects (All):

Human genetics.

Cytology.

Human Genetics.

Cell Biology.

Local Subjects:

Human Genetics.

Cell Biology.

Physical Description:

1 online resource (XLV, 151 pages).

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation et cetera Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology et cetera.

Contents:

Introduction

Materials and Methods

Results-I. Lamin A is an endogenous activator of SIRT6 in DNA damage repair process

Results-II. Haploinsufficiency of p53 rescues lifespan and premature aging-associated abnormalities in Sirt6-deficient mice

Results-III. SIRT6 is an acetylated protein and a NAD+-dependent self-deacetylase

Discussion.

Other Format:

Printed edition:

ISBN:

978-981-32-9267-3

9789813292673

Access Restriction:

Restricted for use by site license.