Protein-protein interactions : computational and experimental tools / edited by Weibo Cai, Hao Hong.

Format:

Book

Author/Creator:

Hao, Hong.

Contributor:

Cai, Weibo, editor.

Hong, Hao, editor.

Language:

English

Subjects (All):

Protein-protein interactions.

Physical Description:

1 online resource (xi, 472 pages) : illustrations

Other Title:

Protein-protein interactions

Place of Publication:

IntechOpen 2012

Rijeka, Croatia : InTech, [2012]

Language Note:

English

Summary:

Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Notes:

Description based on: online resource; title from PDF information screen (InTech, viewed October 17, 2022).

ISBN:

9789535143123

9535143123