DNA Systems Under Internal and External Forcing : An Exploration Using Coarse-Grained Modelling / by Megan Clare Engel.

Format:

Book

Author/Creator:

Engel, Megan Clare, author.

Contributor:

SpringerLink (Online service)

Series:

Physics and Astronomy (Springer-11651)

Springer Theses, Recognizing Outstanding Ph.D. Research,. 2190-5053

Springer Theses, Recognizing Outstanding Ph.D. Research, 2190-5053

Language:

English

Subjects (All):

Nanoscience.

Nanostructures.

Biomathematics.

Chemistry, Physical and theoretical.

Atomic structure.

Molecular structure.

Nanoscale Science and Technology.

Mathematical and Computational Biology.

Theoretical and Computational Chemistry.

Atomic/Molecular Structure and Spectra.

Local Subjects:

Nanoscale Science and Technology.

Mathematical and Computational Biology.

Theoretical and Computational Chemistry.

Atomic/Molecular Structure and Spectra.

Physical Description:

1 online resource (XV, 144 pages) : 70 illustrations, 67 illustrations in color.

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.

Contents:

Introduction

Simulation Methods

Non-equilibrium bio-molecular unfolding under tension

Force-induced unravelling of DNA origami

Measuring internal forces in single-stranded DNA

Conclusions

Appendices.

Other Format:

Printed edition:

ISBN:

978-3-030-25413-1

9783030254131

Access Restriction:

Restricted for use by site license.