The Origin of a New Progenitor Stem Cell Group in Human Development : An Immunohistochemical-, Light- and Electronmicroscopical Analysis / by Hubert Wartenberg, Andreas Miething, Kjeld Møllgård.

Format:

Book

Author/Creator:

Wartenberg, Hubert, author.

Miething, Andreas, 1955- author.

Møllgård, Kjeld, 1942- author.

Contributor:

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Advances in anatomy, embryology, and cell biology 0301-5556 ; 230.

Advances in Anatomy, Embryology and Cell Biology, 0301-5556 ; 230

Language:

English

Subjects (All):

Cytology.

Neurosciences.

Human anatomy.

Cell Biology.

Anatomy.

Local Subjects:

Cell Biology.

Neurosciences.

Anatomy.

Physical Description:

1 online resource (XII, 79 pages) : 78 illustrations, 2 illustrations in color.

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs. The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets. These newly detected stem cells represent a specific developmental step which is found only in humans. .

Contents:

Chapter 1. Distribution of progenitor stem cells from the AMG-system an the adrenal

Chapter 2. Development of the adrenal medulla and other endocrine glands

Chapter 3. Final view on stem cell origin during human development.

Other Format:

Printed edition:

ISBN:

978-3-030-02050-7

9783030020507

Access Restriction:

Restricted for use by site license.