Estrogen Receptor and Breast Cancer : Celebrating the 60th Anniversary of the Discovery of ER / edited by Xiaoting Zhang.

Format:

Book

Contributor:

Zhang, Xiaoting (Professor), editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Cancer drug discovery and development 2196-9906

Cancer Drug Discovery and Development, 2196-9906

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Molecular biology.

Cancer Research.

Molecular Medicine.

Local Subjects:

Cancer Research.

Molecular Medicine.

Physical Description:

1 online resource (XII, 417 pages) : 79 illustrations, 69 illustrations in color.

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Humana, 2019.

System Details:

text file PDF

Summary:

The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Contents:

1. Introduction: On the discovery of Estrogen Receptor

2. Physiological and Pathological Roles of Estrogen Receptor

3. Estrogen Receptor Cofactors

4. ER-Mediated Gene Transcription

5. ER Transcriptome

6. Estrogen Receptor Regulation of Non-Coding RNAs in Breast Cancer

7. First Targeted Therapy

- History of Tamoxifen

8. Selective Estrogen Receptor Modulators (SERMs)

9. New Estrogen Receptor Drugs

10. Endocrine Therapy in Clinical Practice

11. Structural Insights into ER and Anti-Estrogen Therapies

12. Molecular Mechanisms of Endocrine Resistance

13. Estrogen Receptor Mutants in Breast Cancer

14. Estrogen Receptor Beta and Isoforms in Breast Cancer

15. Xenoestrogens, Phytoestrogens and Breast Cancer

16. Emerging Approaches to Overcome Endocrine Resistance.

Other Format:

Printed edition:

ISBN:

978-3-319-99350-8

9783319993508

Access Restriction:

Restricted for use by site license.