Radiopharmaceutical Chemistry / edited by Jason S. Lewis, Albert D. Windhorst, Brian M. Zeglis.

Format:

Book

Contributor:

Lewis, Jason S., editor.

Windhorst, Albert D., editor.

Zeglis, Brian M., editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Language:

English

Subjects (All):

Nuclear medicine.

Nuclear Medicine.

Local Subjects:

Nuclear Medicine.

Physical Description:

1 online resource (XVIII, 651 pages) : 530 illustrations, 318 illustrations in color

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (id est nuclear reactions in reactors), heavy element radiochemistry (id est the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like "The Production of Radionuclides" and "Basics of Radiochemistry". The second section is the main focus of the book. In this section, each chapter's author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a "Best of the Rest" chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including "Bioconjugation Methods," "Click Chemistry in Radiochemistry", and "Radiochemical Instrumentation." This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

Contents:

Part I: First Principles

Why Nuclear Imaging and Radiotherapy

Overview of Nuclear Imaging with Small Molecules

Overview of Nuclear Imaging with Peptides and Proteins

Overview of Nuclear Imaging with Antibodies

Overview of Nuclear Imaging with Nanoparticles

Overview of Targeted Radiotherapy

The Production of Radioisotopes

The Physics of Nuclear Imaging

The Physics of Targeted Radiotherapy

Part II: Radiochemistry

11C

68Ga and 67Ga

18F Part 1: Nucleophilic Fluorinations

18F Part 2: Electrophilic Fluorinations

18F Part 3: Fluorination Using Prosthetic Groups

18F Part 4: Next Generation Fluorination Methods

99mTc

186Re and 188Re

The isotopes of Cu

The isotopes of Y

111In and 177Lu

89Zr

The isotopes of iodine

The chemistry of alpha-emitting isotopes

The best of the rest: the chemistry of emerging isotopes

Part III: Special Topics

Bioconjugation Methods

Click Chemistry in Radiochemistry

Cerenkov Imaging

Imaging Instrumentation for Radiochemists

Medical Physics for Radiochemists

Radiation Safety for Radiochemists

The Clinical Translation Process in the U.S.

The Clinical Translation Process in Europe

Choosing a Target for Nuclear Imaging or Radiotherapy.

Other Format:

Printed edition:

ISBN:

978-3-319-98947-1

9783319989471

Access Restriction:

Restricted for use by site license.