The Unfolded Protein Response in Cancer / edited by Robert Clarke.

Format:

Book

Contributor:

Clarke, Robert, editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Cancer drug discovery and development 2196-9906

Cancer Drug Discovery and Development, 2196-9906

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Cancer Research.

Local Subjects:

Cancer Research.

Physical Description:

1 online resource (XI, 220 pages) : 15 illustrations, 14 illustrations in color.

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Humana, 2019.

System Details:

text file PDF

Summary:

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

Contents:

Introduction: The Unfolded Protein Response

Endoplasmic Reticulum Stress Signaling During Development

Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy

ATF4, Hypoxia and Treatment Resistance in Cancer

Role of Protein Translation in the Unfolded Protein Response

Roles of Spliced and Unspliced XBP1 in Breast Cancer

The Unfolded Protein Response in Triple-Negative Breast Cancer

The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer

Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling

Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases

Index.

Other Format:

Printed edition:

ISBN:

978-3-030-05067-2

9783030050672

Access Restriction:

Restricted for use by site license.