In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials / edited by Toru Takebayashi, Robert Landsiedel, Masashi Gamo.

Format:

Book

Contributor:

Takebayashi, Toru, editor.

Landsiedel, Robert, editor.

Gamō, Masashi, editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Current topics in environmental health and preventive medicine 2364-8333

Current Topics in Environmental Health and Preventive Medicine, 2364-8333

Language:

English

Subjects (All):

Health promotion.

Health administration.

Pharmacology.

Health Promotion and Disease Prevention.

Health Administration.

Pharmacology/Toxicology.

Local Subjects:

Health Promotion and Disease Prevention.

Health Administration.

Pharmacology/Toxicology.

Physical Description:

1 online resource (VI, 223 pages) : 70 illustrations, 62 illustrations in color.

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials. With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.

Contents:

1 The role of in vivo screening studies in assessing manufactured nanomaterials

Part 1 Short Term Inhalation Study

2. The short-term inhalation study (STIS) as a range finder and screening tool in a tiered grouping strategy

3. Use of short-term inhalation study to obtain initial hazard data and prepare for subacute and subchronic inhalation studies, and toxicokinetic studies

4. Subchronic inhalation Toxicity Study with a Vapor Grown Carbon Nanofiber in Male and Female Rats (OECD 413) - Does nanofiber exposure have adverse impacts on the cardiovascular system?

Part 2 Intratracheal Administration Study

5. Comparison of responses in rat lung following inhalation and intratracheal administration of nanoparticles

6. Standardization of intratracheal instillation study of manufactured nanomaterials

7. Sample preparation and the chracterization for Intratracheal Administration

8. Development of intra-tracheal intra-pulmonary spraying (TIPS) as an alternative assay method for testing chronic toxicity and carcinogenic potential of multiwall carbon nanotubes

9. Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study using Intratracheal Administration

10. Toxicokinetics of nano materials after the intratracheal administration

11. In Vitro Alveolar Epithelial Models toward the Prediction of Cytotoxicity Tests and Translocation Studies of Nanoparticles. .

Other Format:

Printed edition:

ISBN:

978-981-13-8433-2

9789811384332

Access Restriction:

Restricted for use by site license.