Diabetic Nephropathy : Pathophysiology and Clinical Aspects / edited by Joris J. Roelofs, Liffert Vogt.

Format:

Book

Contributor:

Roelofs, Joris J., editor.

Vogt, Liffert, editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Language:

English

Subjects (All):

Diabetes.

Pathology.

Local Subjects:

Diabetes.

Pathology.

Physical Description:

1 online resource (XVI, 548 pages) : 81 illustrations, 67 illustrations in color

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.

Contents:

1. Diabetic nephropathy - Scope of the problem

Historical overview of diabetic kidney disease

Clinical features and natural course of diabetic nephropathy

Global, regional and ethnic differences in diabetic nephropathy

Diabetic nephropathy in children and adolescents

Renal disease in obesity, metabolic syndrome and diabesity

2. Pathophysiology and clinical pathology of the diabetic kidney

Introduction to pathogenetic mechanisms of diabetic nephropathy

The genetics of diabetic nephropathy

Pathology of the kidney in diabetes

3. The glomerulus

The mesangial cell in diabetic nephropathy

The glomerular endothelium in diabetic nephropathy - role of heparanase

The podocyte in diabetic nephropathy: recent advances

Inflammatory processes in diabetic glomeruli

4. The tubulointerstitium

Proteinuria and tubulotoxicity

Tubulo-glomerular communication in diabetic nephropathy

Mechanisms of interstitial fibrosis in diabetic nephropathy

5. Microvascular involvement

Microvascular damage and hemodynamic alterations in diabetic nephropathy

Coagulation and hemostasis in diabetic nephropathy

Renal hemodynamics in diabetic kidney disease - relevance for intervention

Microvascular complications in the eye: diabetic retinopathy

6. Macrovascular involvement

Hypertension in diabetic kidney disease

Macrovascular involvement in diabetes - renal artery stenosis

Atherosclerosis and diabetic nephropathy

7. Experimental designs

Animal models of diabetic kidney disease

Clinical trial and error in diabetic nephropathy

8. Therapy of diabetic nephropathy

Treatment goals in diabetic nephropathy

Kidney transplantation and diabetic nephropathy

9. Future developments

Health programs in low- and middle-income countries

OMICs in diabetic kidney disease

Future and novel compounds in the treatment of diabetic nephropathy.

Other Format:

Printed edition:

ISBN:

978-3-319-93521-8

9783319935218

Access Restriction:

Restricted for use by site license.