Targeted Therapies for Lung Cancer / edited by Ravi Salgia.

Format:

Book

Contributor:

Salgia, Ravi, editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Current cancer research 2199-2584

Current Cancer Research, 2199-2584

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Molecular biology.

Cancer Research.

Molecular Medicine.

Local Subjects:

Cancer Research.

Molecular Medicine.

Physical Description:

1 online resource (IX, 238 pages) : 19 illustrations in color.

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient's genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Contents:

1. EGFR

2. ALK

3. ROS1

4. B-RAF

5. MET

6. HER2

7. NTRK

8. SCLC

9. Complexities of the Lung Tumor Microenvironment

10. KRAS

11. Targeting Epigenetic Regulators in Cancer to Overcome Targeted Therapy Resistance.

Other Format:

Printed edition:

ISBN:

978-3-030-17832-1

9783030178321

Access Restriction:

Restricted for use by site license.