Congenital Hyperinsulinism : A Practical Guide to Diagnosis and Management / edited by Diva D. De León-Crutchlow, Charles A. Stanley.

Format:

Book

Contributor:

De León-Crutchlow, Diva D., editor.

Stanley, Charles A., editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Contemporary Endocrinology,. 2523-3785

Contemporary Endocrinology, 2523-3785

Language:

English

Subjects (All):

Endocrinology.

Pediatrics.

Local Subjects:

Endocrinology.

Pediatrics.

Physical Description:

1 online resource (XV, 165 pages) : 22 illustrations, 12 illustrations in color.

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Humana, 2019.

System Details:

text file PDF

Summary:

This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a "personalized" approach to management according to the type of hyperinsulinism, and particularly according to the likelihood of focal hyperinsulinism, is starting to emerge. The opening chapter discusses HI diagnosis using biochemical approaches and phenotype characterization. The various forms of HI are then presented in detail in three main categories: diazoxide-responsive, diazoxide-unresponsive and syndromic HI. Both medical and surgical management strategies are then discussed, covering imaging, histology, surgical approach, and post-operative management. Complications, such as feeding problems, and long-term outcomes, such as neurodevelopmental issues, are carefully considered in the final chapter. Practical and user-friendly, Congenital Hyperinsulinism is the go-to resource for pediatric endocrinologists, residents and fellows, general pediatricians and neonatologists.

Contents:

Approach to the Diagnosis of Neonates and Infants with Persistent Hypoglycemia

Diazoxide-Responsive Forms of Congenital Hyperinsulinism

Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism

Syndromic Causes of Congenital Hyperinsulinism

Molecular Diagnosis of Congenital Hyperinsulinism

Medical Management of Hyperinsulinism

18F-DOPA PET

Histopathology of the Pancreas in Congenital Hyperinsulinism

Surgery for Congenital Hyperinsulinism

Perioperative Management of Hyperinsulinism

Management of the Child with Persistent Hypoglycemia After Surgery

Management of Diabetes and Pancreatic Insufficiency after Pancreatectomy

Feeding Problems in Congenital Hyperinsulinism

Neurodevelopmental Outcomes.

Other Format:

Printed edition:

ISBN:

978-3-030-02961-6

9783030029616

Access Restriction:

Restricted for use by site license.