Crucible of science : the story of the Cori laboratory / John H. Exton.

Format:

Book

Author/Creator:

Exton, John H. (John Howard), 1933-

Language:

English

Subjects (All):

Cori, C. F. (Carl Ferdinand), 1896-1984.

Cori, C. F.

Cori, Gerty T. (Gerty Theresa), 1896-1957.

Cori, Gerty T.

Washington University (Saint Louis, Mo.).

Biochemists--United States--Biography.

Biochemists.

Medicine--Research--Missouri--Saint Louis.

Medicine.

Physical Description:

1 online resource (xvi, 226 pages ) illustrations

Edition:

1st ed.

Place of Publication:

Oxford : Oxford University Press, c2013.

Language Note:

English

Summary:

This title examines the careers of Carl and Gerty Cori, and the other eminent scientists who trained in their laboratory. "Crucible of Science" is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escape deteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to winthe Nobel Prize, the laboratory they established at the University has since produced some of the most outstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental inestablishing the then new science of Biochemistry in the U.S. They applied chemical approaches to elucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme catalysts that carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were above question. This book examines the careers of both Coris and the other eminent scientists who trained in their laboratory. It notes the Coris' acceptance of women, Jews, and scientists from all over the world, unique during this time period. It analyzes those reasons why the laboratory was so successful in attracting the best trainees and producing premier scientists. Intended for scientists, science historians, and anyone interested in the history of science, "Crucible of Science" is a unique presentationof remarkable careers and personalities, examined within the context of the Coris' laboratory.

Contents:

Cover

Contents

Acknowledgments

Introduction

1. Carl and Gerty Cori: Early Life

2. Sidney Colowick: Their First Graduate Student

3. Herman Kalckar: The Great Dane

4. Severo Ochoa: Spanish Genius

5. Move to Enzymology and Work of Arda Green

6. Luis Leloir: One of Argentina's Greatest Scientists

7. Earl Sutherland: Master of Intuition

8. Coris' Move to the Department of Biological Chemistry: Award of Nobel Prizes and Career of Tom Cori

9. Sidney Velick: Modest Enzymologist

10. Victor Najjar: Pediatrician and Immunochemist

11. Edwin Krebs: Accidental Biochemist

12. Mildred Cohn: Against All Odds

13. Christian de Duve: Belgian with Savoir Faire

14. Arthur Kornberg: A Giant of Biochemistry

15. Hormone Effects on Muscle Carbohydrate Metabolism

16. Charles Park: Aristocratic Physiologist

17. Jane Harting Park: Enthusiast for Science

18. Gerty Cori's Work on Glycogen Structure and Glycogen Storage Diseases

19. Joseph Larner: Focus on Glycogen Synthase

20. Contributions of Barbara and David Brown

21. William Daughaday: All About Growth

22. Robert Crane: A Decade with Carl Cori

23. Alberto Sols: Spanish Enzymologist

24. Luis Glaser: The Complexity of Carbohydrates

25. Ernst Helmreich: Jovial Bavarian

26. Carl Frieden: Enzyme Kineticist

27. David Kipnis: Focus on Diabetes

28. William Danforth: Academic Leader

29. The Influence of the Coris on Washington University and Carl Cori's Research at Boston

30. The Heritage of the Coris

Index

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

R

S

T

U

V

W

Y

Z.

Notes:

Formerly CIP.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

0-19-933987-2

0-19-986108-0

OCLC:

922904514