Translational Systems Medicine and Oral Disease / edited by Stephen T. Sonis, Alessandro Villa.

Format:

Book

Contributor:

Sonis, Stephen T.

Villa, Allessandro.

Language:

English

Subjects (All):

Oral medicine--Research.

Oral medicine.

Research.

Genre:

Electronic books.

Physical Description:

1 online resource (460 pages)

Place of Publication:

San Diego : Elsevier Science & Technology, 2019.

System Details:

text file

Contents:

Front Cover; Translational Systems Medicine and Oral Disease; Translational Systems Medicine and Oral Disease; Copyright; Contents; List of contributors; Preface; 1

Introduction to systems medicine; Reductionism; Systems biology and medicine; Systems medicine and oral disease; 2

System biology; Introduction to system biology; Cell biology and networks; Signaling networks; Metabolic networks; Regulatory networks; Omics data; Practical implications; References; 3

Genomic foundation for medical and oral disease translation to clinical assessment; Introduction

The basics of the genomic systemGene code; Non-B DNA; A-motif; I-motif; DNA hairpins; H-DNA; B-DNA; Nucleic acid hybridization; tRNA coding; Pseudogene function; tRNA functionality; Conversion of B DNA into non-B DNA; Helical variations of B-DNA; A-DNA; Z-DNA; Gene coding and noncoding; Histones-chromatin-nucleosomes; Ploidy-aneuploidy; Somatic mutation; Mutation manipulation of genome expression; SNPs; Haplotype genotype variation; Allelic variability; RNAs: other useful functions in genomic expression; miRNA; siRNA; Small activating RNAs; PIWI-interacting RNAs; Small nuclear RNA/U-RNA

Extracellular RNALong noncoding RNAs; SWI/SNF complex; Circular RNA; X-inactive-specific transcript; HOTAIR (HOX (homeobox gene; transcript antisense RNA)); Telomerase RNA component; Y RNA; Cis-natural antisense transcript; Alternate splicing; Transcribed ultraconserved regions; Darwinism influence on genomic expression and risk for disease; Biologic fitness; Factors characterize degeneracy: complexity, evolvability, and robustness; Causality ("cause and effect"); Genetic drift; Why human genetics is difficult to model?; Present status of genomic analysis and determination of disease risk

GenomicsRoad to personalized medicine; References; 4

Proteomics; Introduction; Whole saliva; Definition of proteomics; Salivary proteomics; Proteomic technologies; Mass spectrometry; Emerging MS-based approaches; Selected reaction monitoring-based targeted proteomics; Large-scale targeted proteomics (SWATH); Metaproteomics; The human whole saliva proteomic technologies; Clinical applications of salivary proteomics; Periodontitis and dental caries; Orthodontically induced inflammatory root resorption; Primary Sjögren's Syndrome; Oral squamous cell carcinoma; Gastric cancer; Lung cancer

Breast cancerOvarian cancer; Oral chronic graft-versus-host-disease; Synovitis, acne, pustulosis, hyperostosis and osteitis syndrome; Human immunodeficiency virus; Conclusions; Acknowledgments; References; 5

Metabolomics in head and neck cancer: A summary of findings; Introduction; Saliva metabolomics; Blood and urine metabolomics; Cell and tissue metabolomics; Conclusions and future perspectives; Abbreviations; Acknowledgments; Conflict of Interest Statement; References; 6

Microbiomics; The human microbiome: a general overview; Background and definitions; The many microbiomes

Notes:

Description based upon print version of record.

Roles in human health and disease

Other Format:

Print version: Sonis, Stephen Translational Systems Medicine and Oral Disease

ISBN:

9780128137635

0128137630

OCLC:

1120695816

Access Restriction:

Restricted for use by site license.