Chronic Myeloid Leukemia / edited by Rüdiger Hehlmann.

Format:

Book

Contributor:

Hehlmann, Rüdiger, editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Hematologic Malignancies,. 2197-9766

Hematologic Malignancies, 2197-9766

Language:

English

Subjects (All):

Hematology.

Local Subjects:

Hematology.

Physical Description:

1 online resource (X, 255 pages) : 40 illustrations, 39 illustrations in color.

Edition:

First edition 2016.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib. .

Contents:

Cytogenetics of CML

The biology and pathogenesis of CML

The choice of 1st line CML-treatment

A review and up-date of the European LeukemiaNet recommendations for the management of CML

Management of adverse events associated with ATP-competitive BCR-ABL 1 tyrosine kinase inhibitors in CML

Standardization of molecular monitoring for CML

Epidemiology of CML

Prognostic scores for patients with CML under particular consideration of disease specific death

Response-related predictors of survival

CML- blast crisis: implications and management

Chronic Myeloid Leukemia and Pregnancy

The role of hematopoietic stem cell transplantation in CML

Discontinuation or cessation of tyrosine kinase inhibitor treatment in CML patients with deep molecular response

The interferon-alpha revival in CML

Changing the cost of care for CML: the availability of generic imatinib.

Other Format:

Printed edition:

ISBN:

978-3-319-33198-0

9783319331980

Access Restriction:

Restricted for use by site license.