Hepatocellular Carcinoma : Diagnosis and Treatment / edited by Brian I. Carr.

Format:

Book

Contributor:

Carr, Brian I., editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Current clinical oncology 2364-1134

Current Clinical Oncology, 2364-1134

Language:

English

Subjects (All):

Oncology.

Clinical medicine.

Cancer--Surgery.

Cancer.

Gastroenterology.

Hepatology.

Surgical Oncology.

Local Subjects:

Oncology.

Hepatology.

Surgical Oncology.

Gastroenterology.

Physical Description:

1 online resource (XXI, 596 pages) : 129 illustrations, 80 illustrations in color.

Edition:

Third edition 2016.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC indidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists. "This is a well written text and should be a good reference book for those who see patients with HCC.." - Practical Gastroenterology "...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC." - Digestive and Liver Disease.

Contents:

Part A. Causes, Biological and Molecular bases of HCC

Chapter 1. Epidemiology of Hepatocellular Carcinoma

Chapter 2. Environmental Carcinogens and Risk for Human Liver Cancer

Chapter 3. Molecular Mechanisms of Hepatocellular Carcinoma

Chapter 4. Chemically-Induced Hepatocarcinogenesis

Chapter 5. Molecular Profiling of Human Hepatocellular Carcinoma

Chapter 6. Genomic signatures of risk factors and molecular identification of HCC subtypes

Chapter 7. MicroRNAs and hepatocellular carcinoma

Chapter 8. Non-tumor prognostic factors in hepatocellular carcinoma

Chapter 9. Gut microbiota and HCC

Chapter 10. Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer

Chapter 11. HCC and its Microenvironment

Chapter 12. Circulating tumor cells (Liquid Tumor Biopsy) in hepatocellular carcinoma: biology, methodologies, and clinical implications

Chapter 13. Role of the immune system in hepatocellular carcinoma: Implications for existing and novel therapies

Chapter 14. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma

Chapter 15. Systemic inflammation: a new prognostic domain and source of therapeutic targets in hepatocellular carcinoma

Chapter 16. Hepatocellular Carcinoma Associated with Hepatitis B virus

Chapter 17. Hepatitis C and Hepatocellular Carcinoma

Chapter 18. Obesity, NASH and HCC

Chapter 19. Metabolic Disease and Hepatocellular Carcinoma

Part B. Diagnosis

Chapter 20. Pathologic Aspects of Hepatocellular Tumors

Chapter 21. Protein biomarkers in the management of hepatocellular carcinoma: Novel combinatory approaches

Chapter 22. Surveillance for hepatocellular carcinoma

Chapter 23. Use of Imaging Techniques to Screen for Hepatocellular Carcinoma

Chapter 24. Ultrasound of Hepatocellular Carcinoma: The Important Contribution of Contrast Enhancement

Chapter 25. MRI for Detection and Evaluation of Hepatocellular Carcinoma

Chapter 26. Computed Tomography of HCC

Chapter 27. Clinical features and clinician's diagnostic approach to hepatocellular carcinoma

Chapter 28. Current HCC Staging systems: their uses and limitations

Part C. Therapies

Chapter 29. Percutaneous Ethanol Injection

Chapter 30. Thermal Ablative Treatments For Hepatocellular Carcinoma

Chapter 31. Resection of Hepatocellular Carcinoma

Chapter 32. Liver Transplantation for Hepatocellular Carcinoma

Chapter 33. Medical Therapy of HCC

Chapter 34. Targeted therapies for Hepatocellular Carcinoma

Chapter 35. Radiation Therapy for Hepatocellular Carcinoma

Chapter 36. Psychosocial Issues in Hepatocellular carcinoma

Chapter 37. Bringing it all together.

Other Format:

Printed edition:

ISBN:

978-3-319-34214-6

9783319342146

Access Restriction:

Restricted for use by site license.