The lymphatic system in health and disease / J. Winny Yun, J. Steven Alexander.

Format:

Book

Author/Creator:

Yun, J. Winny, author.

Alexander, J. Steven, author.

Series:

Colloquium digital library of life sciences

Colloquium series on integrated systems physiology ; # 85.

Colloquium series on integrated systems physiology ; 85

Language:

English

Subjects (All):

Lymphatics.

Lymphatic System.

Medical Subjects:

Lymphatic System.

Physical Description:

1 online resource (xiv, 89 pages) : illustrations.

Place of Publication:

[San Rafael, California] : Morgan & Claypool, 2018.

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat reader.

text file

Summary:

The lymphatic system develops and functions in parallel with the blood circulatory system (termed the "hemovasculature") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens--providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar. This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.

Contents:

1. Introduction

1.1 Lymphatics in history

1.2 The lymphatic system

1.3 Lymph flow as described by Starling

1.4 Development of lymphatics

1.5 Lymphatic endothelial cells

1.6 Lymphatic endothelial specific markers

1.6.1 Prox-1

1.6.2 COUP-TFII

1.6.3 VEGFR-3

1.6.4 VEGF-C

1.6.5 VEGF-D

1.6.6 LYVE-1

1.6.7 FOXC2

1.6.8 Podoplanin

1.6.9 Reelin

1.7 Blood vs. lymphatic endothelial specific markers

1.8 Blood and lymphatic vessel separation

1.8.1 Other regulators of lymphatic patterning

1.8.2 Lymphatic barrier function

1.9 Lymphatics and leukocyte trafficking

2. Lymphatics in different organ systems

2.1 The brain

2.2 The eye

2.2.1 The lungs

2.2.2 Tonsils

2.2.3 Salivary glands

2.2.4 Stomach

2.2.5 Intestinal lymphatics

2.2.6 Lymphatics within the small intestine

2.2.7 Lymphatics within the large intestine

2.3 Lymphatics and protein-losing enteropathies

2.4 Other forms of protein-losing enteropathies

2.5 Intestinal lymphatic hypoplasia

2.5.1 Liver

2.6 Cirrhosis

2.7 Roles of lymphatics in the development of ascites

2.7.1 Gallbladder

2.7.2 Pancreas

2.7.3 Renal (kidney) lymphatics

2.7.4 Myocardial (heart) lymphatics

2.8 Skeletal muscle lymphatics

2.9 Lymphatics as a hormone transport system?

3. Lymphatics in pathophysiological states

3.1 Lymphatic disturbances intensifying chronic inflammatory disease

3.2 Lymphedema

3.3 Diagnosis of lymphedema

3.4 Clinical complications of lymphedema

3.5 Lymphedema distichiasis

3.6 Nonne-Milroy-Meige syndrome

3.6.1 Nonne-Milroy disease and Meige's syndrome

3.7 Hennekam's syndrome

3.8 Sharp-Aagenaes syndrome

3.9 Noonan syndrome

3.10 Yellow nail syndrome

3.11 Lymphangiomatosis

3.12 Gorham-Stout's disease and lymphangiomatosis

3.13 Klippel-Trenaunay syndrome

3.14 Lymphangioleiomyomatosis (LAM)

3.15 Kaposi's Sarcoma

3.16 Cancer and lymphatics

3.17 Lymphatic distress following cancer therapy

3.18 Whipple's disease

3.19 Shock, lymph, and the GI system

3.20 Sjögren's disease

3.21 Lymphatic pathophysiology in GI diseases

3.22 Menetrier's disease

3.23 Heritable risk for developing post-surgical lymphedema

3.24 Organ transplantation and lymphatics

3.25 Evidence for genes that cause abnormal thoracic duct/ intestinal lymphatic system structure

3.26 Relationships between lymphatic modulators and obesity

3.27 Treatments for lymphedema

3.28 Compressive garments and lymphedema

3.29 Drug treatments for lymphedema

3.30 Surgical approaches

3.31 Coumarin

3.32 Horse chestnut extract (HCE)

3.33 Flavonoids

3.34 Tacrolimus

3.35 TGF-beta antagonists

3.36 Tumor necrosis factor-[alpha] (TNF-[alpha]) antagonists

3.37 Leukotriene B4

3.38 Therapeutic lymphangiogenesis

4. Seminal advancements and future directions

References

Author biographies.

Notes:

Part of: Colloquium digital library of life sciences.

Includes bibliographical references (pages 65-87).

Title from PDF title page (viewed on November 28, 2018).

Other Format:

Print version:

ISBN:

9781615047925

OCLC:

1076493798

Access Restriction:

Restricted for use by site license.