Platelets editor: Alan D. Michelson ; associate editors: Marco Cattaneo, Andrew L. Frelinger, Peter J. Newman

Format:

Book

Contributor:

Michelson, Alan D., editor.

Cattaneo, M., editor.

Frelinger, Andrew L., editor.

Newman, Peter J., editor.

Language:

English

Subjects (All):

Blood platelets.

Blood platelet disorders.

Blood Platelets.

Blood Platelet Disorders.

Medical Subjects:

Blood Platelets.

Blood Platelet Disorders.

Physical Description:

1 online resource

Edition:

Fourth edition

Place of Publication:

London, United Kingdom Academic Press, an imprint of Elsevier 2019

System Details:

text file

Summary:

"Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and therapy to increase platelet numbers and/or function. Since the publication of the Third Edition of Platelets, there has been a rapid expansion of knowledge in both basic biology of platelets and the clinical approach to platelet-related diseases. This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource."--Website publisher

Contents:

Front Cover; Platelets; Copyright; Contents; Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; The Role of Platelets in Human Hemostasis, Platelet Transfusion, and Bleeding Time; Immune Thrombocytopenia; Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; Platelet Physiology, Assays of Platelet ``Adhesiveness, ́́ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Antag ... ; Aspirin, Arachidonic Acid, Prostaglandins, Eicosanoids, Nitric Oxide, Endothelial Ecto-ADPase (CD39), Angiogenesis, Micropa ..

A Comparison of Human Platelets and Limulus AmebocytesThe Evolution of Hemostasis and Blood Coagulation; Megakaryocytes and Mammals; Marine Mammals; Order Monotremata; Order Marsupialia; Platelet Levels; A Comparison of Nonplacental and Placental Mammals; Conclusions; References; Chapter 2: Megakaryocyte Development and Platelet Formation; Introduction; Megakaryocyte Development; The Hematopoietic Program; Committed Megakaryocyte Progenitor Cells; Immediate Megakaryocyte Precursors; Endomitosis and Polyploid Formation; Megakaryocyte Cytoplasmic Maturation; Invaginated Membrane System

Dense Tubular SystemGranules; Platelet Formation; Mechanisms of Platelet Production; Budding From the Megakaryocyte Surface; Cytoplasmic Fragmentation via the Invaginated Membrane System; Proplatelet Formation; The Proplatelet Theory; Proplatelet Morphogenesis; The Cytoskeletal Mechanics of Proplatelet Formation; Microtubules Power Proplatelet Elongation; Actin-Dependent Proplatelet Branching; Organelle Transport in Proplatelets; Spectrin-Based Membrane Skeleton in Platelet Production; Release of Platelets; The Sites of Platelet Formation In Vivo; Platelet Formation in the Bone Marrow

Clot Retraction, Glanzmann Thrombasthenia, GPIIb/IIIa Receptor, and αIIbβ3 (GPIIb/IIIa) AntagonistsBernard-Soulier Syndrome, the GPIb-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopenic P ... ; Thrombin-Induced Platelet Activation; Platelets, Metastases, Sialic Acid, Platelet Aging, Sepsis, and Platelet Survival; Reflections on the Past and Thoughts About the Future; References; Part I: Platelet Biology; Chapter 1: The Evolution of Mammalian Platelets; Introduction; Invertebrates; Nonmammalian Vertebrates; Comparative Hemostasis

Platelet Formation in the BloodstreamPlatelet Formation in the Lung; Apoptosis and Platelet Production; Production of Platelets for Infusion; Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; Transcription Factors; GATA-1; Nuclear Factor-Erythroid 2; Cytoskeletal Proteins; β1-Tubulin; Glycoprotein Ib-IX-V Complex; Filamin A; Nonmuscle Myosin Heavy Chain A; ADF/Cofilin; Profilin1A and WASP/WIP; Arp2/3; CIP4/Pacsin2/Dynamin; Rab Geranylgeranyl Transferase; Concluding Remarks; References; Chapter 3: The Structure of Resting and Activated Platelets; Introduction

Notes:

Includes index

Online resource; title from PDF title page (ScienceDirect, viewed March 14, 2019)

Includes bibliographical references and index

Other Format:

Print version :

ISBN:

9780128134696

0128134690

OCLC:

1089804549

Access Restriction:

Restricted for use by site license