An introduction to systems biology : design principles of biological circuits / Uri Alon.

Format:

Book

Manuscript

Author/Creator:

Alon, Uri, 1969- author.

Series:

Wiley series in mathematical and computational biology

Mathematical and computational biology

Chapman & Hall/CRC mathematical and computational biology series

Language:

English

Subjects (All):

Systems biology.

Computational biology.

Biological systems--Mathematical models.

Biological systems.

Physical Description:

xviii, 322 pages : illustrations (some color) ; 26 cm.

Edition:

Second edition.

Place of Publication:

Boca Raton, Fla. : CRC Press, [2019]

Summary:

Praise for the first edition: -- ... superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. - Nature -- [This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology ... It assumes no prior knowledge of or even interest in biology ... One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. ... Alon's book should become a standard part of the training of graduate students. - Physics Today -- Written for students and researchers, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological systems. It highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade. Features: Includes seven new chapters The new edition has 189 exercises, the previous edition had 66 Offers new examples relevant to human physiology and disease The book website including course videos can be found here: https://www.weizmann.ac.il/mcb/UriAlon/introduction-systems-biology-design-principles-biological-circuits.

Contents:

Part one: Network motifs

Transcription networks basic concepts

Autoregulation

The feed forward loop

Temporal programs and the global structure of transcription networks

Positive feedback, bistability and memory

How to build a biological oscillator

Robustness

Kinetic proofreading and conformational proofreading

Part two: Robust signalling

Chemotaxis

Fold-change detection

Dynamical compensation and mutal resistance in tissues

Robust spatial patterning in development

Part three: Optimality

Optimal gene circuit design

Multi-objective optimality in biology

Modularity.

Notes:

Includes bibliographical references and index.

Other Format:

ebook version :

ISBN:

9781439837177

1439837171

9781138490116

1138490113

OCLC:

1089277366