Adhesion in pharmaceutical, biomedical and dental fields / edited by K.L. Mittal and F.M. Etzler.

Format:

Book

Contributor:

Mittal, K. L., 1945- editor.

Etzler, F. M. (Frank M.), editor.

Series:

Adhesion and adhesives : fundamental and applied aspects.

THEi Wiley ebooks.

Adhesion and adhesives : fundamental and applied aspects

THEi Wiley ebooks

Language:

English

Subjects (All):

Adhesives.

Biomedical materials.

Pharmaceutical industry--Technological innovations.

Pharmaceutical industry.

Dental bonding.

Physical Description:

1 online resource (409 pages) : illustrations, tables.

Edition:

1st ed.

Place of Publication:

Beverly, Mass. : Scrivener, 2017.

System Details:

Access using campus network via VPN at home (THEi Users Only).

Summary:

The only book to cover adhesion in pharmaceutical, biomedical and dental fields The phenomenon of adhesion is of cardinal importance in the pharmaceutical, biomedical and dental fields. A few eclectic examples will suffice to underscore the importance/relevance of adhesion in these three areas. For example, the adhesion between powdered solids is of crucial importance in tablet manufacture. The interaction between biodevices (e.g., stents, bio-implants) and body environment dictates the performance of such devices, and there is burgeoning research activity in modifying the surfaces of such implements to render them compatible with bodily components. In the field of dentistry, the modern trend is to shift from retaining of restorative materials by mechanical interlocking to adhesive bonding. The book contains 15 chapters written by internationally-renowned subject matter experts and is divided into four parts: Part 1: General Topics; Part 2: Adhesion in Pharmaceutical Field; Part 3: Adhesion in Biomedical Field; and Part 4: Adhesion in Dental Field. The topics covered include: Theories or mechanisms of adhesion; wettability of powders; role of surface free energy in tablet strength and powder flow behavior; mucoadhesive polymers for drug delivery systems; transdermal patches; skin adhesion in long-wear cosmetics; factors affecting microbial adhesion; biofouling and ways to mitigate it; adhesion of coatings on surgical tools and bio-implants; adhesion in fabrication of microarrays in clinical diagnostics; antibacterial polymers for dental adhesives and composites; evolution of dental adhesives; and testing of dental adhesive joints.

Contents:

Cover

Title Page

Copyright Page

Contents

Preface

Part 1 General Topics

1 Theories and Mechanisms of Adhesion in the Pharmaceutical, Biomedical and Dental Fields

1.1 Introduction

1.1.1 Adherend Material Properties Relevant to Adhesion

1.1.2 Length Scale of Adherend-Adhesive Interactions

1.2 Mechanisms of Adhesion

1.2.1 Mechanical Interlocking Theory

1.2.2 Electrostatic Theory

1.2.3 Wettability, Surface Free Energy, Thermodynamic Adhesion Theory

1.2.4 Diffusion Theory

1.2.5 Chemical (Covalent) Bonding Theory

1.2.5.1 Hydrogen Bonding Theory

1.2.6 Acid-Base Theory

1.2.7 Weak Boundary Layers Concept

1.2.8 Special Mechanism of Elastomeric-Based Adhesives

1.3 Summary

References

2 Wettability of Powders

2.1 Introduction

2.2 Different Forms of Wetting

2.3 Hydrophilic and Hydrophobic Surfaces

2.4 Contact Angle Measurement in Wettability Studies of Powdered Materials

2.5 Contact Angle and Surface Free Energy

2.6 Surface Free Energy Determination of Powdered Solids by Thin Layer Wicking Method

2.7 Surface Free Energy Determination of Powdered Solids by Imbibition Drainage Method

2.8 Summary

Acknowledgement

Part 2 Adhesion in the Pharmaceutical Field

3 Tablet Tensile Strength: Role of Surface Free Energy

3.1 Introduction

3.1.1 Overview

3.1.2 Densification of Powders under Pressure

3.1.3 Measurement of Tablet Tensile Strength

3.1.4 The Ryshkewitch-Duckworth Equation

3.1.5 Surface Science of Adhesion

3.1.6 A Model to Predict the Tensile Strength of Tablets from Individual Components

3.2 Applicability of the Proposed Model to Pharmaceutical Materials

3.2.1 Experimental Details

3.2.2 Ryshkewitch-Duckworth Equation as a Predictor of the Tensile Strength of Binary Mixtures

3.2.3 Dependence on Processing Parameters.

3.2.4 Direct Evidence for the Role of Surface Free Energy

3.3 Discussion

3.4 Summary

3.5 Acknowledgements

4 Role of Surface Free Energy in Powder Behavior and Tablet Strength

4.1 Introduction

4.2 Surface Free Energy

4.3 Role of Surface Free Energy in Solid Wetting

4.4 Role of Surface Free Energy in Powder Flow

4.5 Role of Surface Free Energy in Powder Tableting

4.6 Concluding Remarks

5 Mucoadhesive Polymers for Drug Delivery Systems

5.1 Introduction

5.1.1 Assessment of Mucoadhesive Interactions

5.2 Mucoadhesive Drug Delivery Systems

5.2.1 Benefits of Mucoadhesive Drug Delivery Systems

5.3 Mucoadhesive Polymers

5.3.1 Properties of an Ideal Mucoadhesive Polymer

5.3.2 Classification of Mucoadhesive Polymers

5.3.2.1 First-Generation Polymers

5.3.2.2 Second-Generation Polymers

5.4 Summary

6 Transdermal Patches: An Overview

6.1 Introduction

6.2 Factors Affecting Skin Absorption

6.3 Passive Transdermal Drug Delivery Systems

6.4 Types, Structural Components and Materials Used to Design Passive TDDS

6.4.1 Backing Membrane

6.4.2 Reservoir Layer

6.4.3 Permeation Enhancers

6.4.4 Drug &amp

Skin Contact Adhesive Layer

6.4.5 Disposable Release Liner Layer

6.5 Active Transdermal Drug Delivery Systems

6.6 Production of Transdermal Patches

6.7 Biopharmaceutical Concerns

6.8 Pharmacokinetics of Transdermal Absorption

6.9 Manufacture, Design and Quality Control

6.10 Commercialized Patches

6.11 Regulatory Aspects

6.11.1 Stability Assessment

6.11.2 Safety Assessment

6.11.3 Efficacy Assessment

6.12 Summary and Future Prospects

Acknowledgment

7 Film-Forming Technology and Skin Adhesion in Long-Wear Cosmetics

7.1 Introduction

7.2 Long-Wear Foundation: An overview.

7.3 Effect of Skin Substrate on Adhesion

7.3.1 Skin

7.3.2 Skin Surface Free Energy

7.3.3 Friction of the Skin

7.3.4 Skin Elasticity

7.3.5 Sebum and Sweat

7.3.6 Trans-Epidermal Water Loss (TEWL)

7.4 Long-Wear Technologies in Cosmetic Applications

7.4.1 Review of Silicone Technology

7.4.2 Use of Silicone in Long-Wear Cosmetic Products

7.4.2.1 MQ Resin Technology

7.4.2.2 T-propyl Silsesquioxane in Cosmetics

7.4.2.3 Silicone Acrylate in Foundation

7.5 Summary and Prospects

Acknowledgements

Part 3 Adhesion in the Biomedical Field

8 Factors Affecting Microbial Adhesion

8.1 Introduction

8.1.1 General

8.1.2 Impact of the Environment on Bacterial Adhesion

8.1.3 Adhesion to Specific Surfaces

8.1.4 Implication for Human Health

8.1.5 Factors Affecting Bacterial Adhesion

8.2 Surface Characterization

8.3 Bacterial Adhesion to Material Surfaces

8.4 Summary

Acknowledgments

9 Factors Influencing Biofouling and Use of Polymeric Materials to Mitigate It

9.1 Introduction

9.2 Origin of Biofouling

9.3 Prevention of Micro-Organisms Adhesion

9.3.1 Key Parameters Important in the Prevention of Adhesion

9.3.2 Effect of Surface Composition: Hydrophilic/Superhydrophilic Substrates

9.3.3 Effect of Surface Composition: Hydrophobic Substrates

9.3.4 Effect of Surface Composition: Amphiphilic Surfaces

9.3.5 Effect of Surface Composition: Contra-Hydrophilic Surfaces

9.4 Influence of Mechanical Properties

9.5 Influence of Surface Topography

9.6 Concluding Remarks

10 Coatings on Surgical Tools and How to Promote Adhesion of Bio-Friendly Coatings on Their Surfaces

10.1 Introduction

10.2 Coatings on Various Surgical Tools and Implants in Different Fields of Operative Care to Patients

10.2.1 Neurology.

10.2.1.1 Surgical Tools in Neurology

10.2.1.2 Medical Implants in Neurology

10.2.2 Cardiology

10.2.2.1 Surgical Tools in Cardiology

10.2.2.2 Cardiological Medical Implants

10.2.3 Orthopedics

10.2.3.1 Surgical Tools for Orthopedic Care

10.2.3.2 Medical Implants for Orthopedic Care

10.2.4 Dentistry

10.2.4.1 Surgical Tools Related to Dentistry

10.2.4.2 Medical Implants Related to Dentistry

10.2.5 Ophthalmology

10.2.5.1 Surgical Tools Related to Ophthalmology

10.2.5.2 Medical Implants Related to Ophthalmology

10.3 Promotion of Adhesion of Bio-Friendly Coatings on Surfaces of Tools and Implants

10.3.1 Bio-Friendly Coatings

10.3.2 Adhesion

10.3.3 Methods Used for Promotion of Adhesion

10.4 Summary

11 Techniques for Deposition of Coatings with Enhanced Adhesion to Bio-Implants

11.1 Bio-Implants: An Introduction

11.1.1 Adhesion of Coatings to Implants

11.2 Deposition Methods for Enhanced Adhesion of Coatings on Implants

11.2.1 Radio-Frequency (RF) Magnetron Sputtering

11.2.1.1 Adhesion Strength

11.2.2 Plasma Spraying Process

11.2.2.1 Adhesion Strength

11.2.3 Pulsed Laser Deposition

11.2.3.1 Adhesion Strength

11.3 Summary

12 Relevance of Adhesion in Fabrication of Microarrays in Clinical Diagnostics

12.1 Introduction

12.2 Protein Microarrays

12.2.1 Fabrication Techniques

12.2.2 Adhesion of Probes in Protein Microarray Fabrication

12.2.2.1 Protein Microarray on Glass

12.2.2.2 Protein Microarray on Gold Substrate

12.2.2.3 Protein Microarrays on Polymer Substrate

12.2.2.4 Protein Microarrays on other Substrates

12.2.2.5 Microarrays Fabrication: Substrate Selection and Modifications

12.3 DNA Microarrays

12.3.1 Adhesion of Probes in DNA Microarray Fabrication

12.3.1.1 Immobilization by Physical Adsorption.

12.3.1.2 Covalent-Assisted Immobilization

12.3.1.3 Immobilization by Streptavidin-Biotin Interactions

12.3.1.4 Immobilization by Nanocones

12.3.1.5 Selection of Support Material

12.4 Antibody Microarrays

12.4.1 Fabrication Techniques for Antibody Microarrays

12.4.2 Role of Adhesion in Antibody Immobilization

12.5 Summary

Part 4 Adhesion in the Dental Field

13 Antibacterial Polymers for Dental Adhesives and Composites

13.1 Introduction

13.2 Major Damage from Oral Biofilm Formed: The Acid Production

13.3 The Chemistry of Current Dental Adhesives and Composites

13.4 The Need for Treatments Targeting Oral Cariogenic Biofilms

13.5 Classification of Antibacterial Polymers for Dental Materials

13.5.1 Non-Covalent Incorporation of Antibacterial Agents into Monomers

13.5.2 Inherently Antibacterial Polymers

13.6 Mechanisms of Action of Antibacterial Monomers

13.7 Antibacterial Properties of Dental Adhesives and Composites Containing Antibacterial Monomers

13.8 Considerations of Mechanical Properties

13.9 Summary and Prospects

14 Dental Adhesives: From Earlier Products to Bioactive and Smart Materials

14.1 Introduction

14.2 Adhesion to Dental Substrates

14.2.1 Fundamentals

14.2.2 Principles/Concepts of Adhesion

14.2.3 Bonding to Enamel

14.2.4 Bonding to Dentin

14.2.5 Adhesive Systems

14.3 Adhesive Strategies

14.3.1 Etch-and-Rinse Adhesive Systems

14.3.2 Self-Etch Adhesive Systems

14.3.3 Universal/Multi-Mode Adhesives

14.4 Limitations in Bonding to Dental Substrates

14.5 Strategies to Reduce Bond Strength Degradation - Current Advances

14.5.1 Protease Inhibitors

14.5.1.1 Cationic Agents

14.5.1.2 Cross-Linking Agents

14.5.1.3 Zinc Methacrylate

14.5.1.4 Polyphenols

14.5.2 Reinforcing Compounds.

14.5.2.1 Nanoparticles.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781523115068

1523115068

9781119323785

1119323789

9781119323716

1119323711

9781119323792

1119323797

OCLC:

983786603