Biodegradable thermogels / edited by Xian Jun Loh and David James Young.

Format:

Book

Contributor:

Loh, Xian Jun, editor.

Young, David James, editor.

Series:

ISSN

Language:

English

Subjects (All):

Polymers in medicine.

Physical Description:

1 online resource (199 pages) : illustrations

Edition:

1st ed.

Place of Publication:

London, England : Royal Society of Chemistry, 2019.

Summary:

Biodegradable thermogels are a promising class of stimuli-responsive polymers. This book summarizes recent developments in thermogel research with a focus on synthesis and self-assembly mechanisms, gel biodegradability, and applications for drug delivery, cell encapsulation and tissue engineering.

Contents:

Cover

Preface

Contents

Chapter 1 Thermogelling Polymers and Their History

1.1 Introduction

1.2 Synthesis

1.3 Micellization and Thermogelling Properties

1.3.1 Gelation Mechanism

1.3.2 Kinetics of Micellization

1.3.3 Formation of Micelles with Different Morphologies

1.4 Pluronic Systems in the Biomedical Sciences

1.4.1 Early Uses

1.4.2 Wound Healing

1.4.3 Drug Delivery

1.5 Disadvantages of Pluronic Systems

1.6 Modifications of Pluronic Copolymers

1.6.1 Modified Pluronic Copolymers for Improved Mechanical Properties

1.6.2 Modified Pluronic Copolymers for Improved Biodegradability

1.7 Modern Applications of Pluronics

1.8 Future Perspectives

References

Chapter 2 Thermogelling PLGA-based Copolymers

2.1 History and Structures

2.2 Synthesis

2.3 Properties

2.3.1 Reversible Sol-to-gel Transition

2.3.2 Degradation

2.3.3 Biocompatibility

2.4 Applications

2.4.1 Drug Release

2.4.2 Gene Delivery

2.4.3 Postoperative Adhesion Prevention

2.5 Areas for Future Research

2.6 Conclusions

Chapter 3 Polyester-based Biodegradable Thermogelling Systems as Emerging Materials for Therapeutic Applications

3.1 Introduction

3.2 Polyester-based Thermogelling Systems

3.2.1 The Poly(lactic acid)-based Thermogelling Systems

3.2.2 Polycaprolactone-based Thermogelling Systems

3.2.3 Poly([R]-3-hydroxybutyrate)-based Thermogelling System

3.2.4 Poly(glycerol sebacate)-based Thermogelling Systems

3.3 Application of Polyester-based Thermogelling Systems

3.3.1 Therapeutic Delivery

3.3.2 Tissue Engineering

3.4 Conclusion

Abbreviations

Chapter 4 Biodegradable Thermogelling Polymers for Drug Delivery

4.1 Introduction

4.2 Thermogelling Mechanism

4.3 Mechanism of Drug Release in Thermogels.

4.4 Advantages and Disadvantages of Thermogelling Polymeric Materials Compared to Other Drug-delivery Methods

4.5 Delivery of Insulin and Protein Drugs in the Treatment of Diabetes

4.6 Adaptation of Thermogels for Biomedical Applications

4.6.1 Selenium-containing Thermogels

4.6.2 Matrix Metalloproteinase-sensitive Thermogelling Polymers

4.7 Towards Understanding In-vivo Effectiveness of Polymeric Thermogel Drug Delivery

4.7.1 Toxicological Aspects of the Use of Dextran Microspheres and Thermogelling Ethyl(hydroxyethyl) Cellulose as Nasal Drug-delivery Systems

4.7.2 In-vivo Pharmacological Evaluations of an Antioxidant-loaded Biodegradable Thermogel

4.8 Conclusion

Chapter 5 Injectable Thermogelling Polymers for Bone and Cartilage Tissue Engineering

5.1 Introduction

5.2 Scaffold Requirements for Bone and Cartilage Tissue Engineering

5.3 Chemistry and Properties of Selected Injectable Thermogelling Scaffolds

5.3.1 Totally Non-degradable Polymers

5.3.2 Enzymatically Degradable Polymers

5.3.3 Hydrolytically Degradable Polymers

5.4 Conclusions

Chapter 6 Thermogels for Stem Cell Culture

6.1 Introduction

6.2 Thermogel 3D Scaffolds for Proliferation and Chondrogenic Differentiation of Stem Cells

6.3 3D Thermogel Scaffold for Proliferation and Osteogenic Differentiation of Stem Cells

6.4 Thermogel 3D Scaffold for Proliferation and Adipogenic Differentiation of Stem Cells

6.5 Conclusion

Chapter 7 Degradation Behaviour of Biodegradable Thermogels

7.1 Introduction

7.2 Relevance of Thermogels

7.2.1 Drug Delivery

7.2.2 Tissue Engineering

7.3 Importance of Degradability

7.4 Biodegradation

7.4.1 Surface Erosion

7.4.2 Bulk Erosion

7.4.3 Enzymatic Degradation

7.5 In Vivo Degradation

7.6 Factors Affecting the Degradation Rate.

7.6.1 Material Properties

7.6.2 Packing of Micelles

7.6.3 Bond Type

7.6.4 Ratio of Hydrophilic to Hydrophobic Sections

7.6.5 Number of Sites for Enzymatic Action

7.7 Techniques to Study the Degradable Behaviour of Thermogels

7.7.1 Mass Loss

7.7.2 Molecular Weight Comparison

7.7.3 Surface Topography (Scanning Electron Microscopy)

7.7.4 Fourier-transform Infrared Spectroscopy

7.7.5 Nuclear Magnetic Resonance Spectroscopy

7.7.6 Technique Comparison

7.8 Future Perspective

Chapter 8 From Bench to Bedside - OncoGel™, an In Situ Hydrogel for In Vivo Applications

8.1 Introduction

8.2 Non-clinical Safety and Efficacy Evaluation

8.2.1 Safety Studies

8.2.2 Tissue Distribution Studies

8.3 Development of OncoGel™ as a Potential Cancer Therapeutic Drug

8.3.1 Rat Model Studies

8.3.2 Pig Model Studies

8.3.3 Human Clinical Trials

8.4 Perspective

Chapter 9 Hydrogel-based 3D Scaffolds for Stem Cell Culturing and Differentiation

9.1 Introduction

9.2 Hydrogel-based 3D Culturing and Differentiation of Stem Cells

9.3 Hydrogel-based 3D Scaffolds Induce Stem-cell-specific Differentiation

9.3.1 Scaffold-induced Neuronal Differentiation

9.3.2 Scaffold-induced Hepatogenic Differentiation

9.3.3 Scaffold Induced Chondrogenesis Differentiation

9.3.4 Scaffold-induced Osteogenic Differentiation

9.3.5 Scaffold-induced Adipogenic Differentiation

9.4 Conclusion

Chapter 10 Beyond Thermogels - Other Forms of Noncovalently Formed Polymeric Hydrogels

10.1 Introduction

10.2 Key Features of Noncovalent Polymeric Hydrogels

10.3 Types of Noncovalent Polymeric Hydrogels

10.3.1 Host-Guest-mediated Supramolecular Hydrogels

10.3.2 Noncovalent Hydrogels through Hydrophobic Association.

10.3.3 Noncovalent Polymeric Hydrogels Through Forming Ionic Bonds

10.3.4 Dynamic Covalent Bond-based Polymeric Hydrogels

10.4 Summary and Outlook

Subject Index.

Notes:

Description based on print version record.

ISBN:

9781523122967

152312296X

9781788015394

1788015398

9781788012676

1788012674

OCLC:

1057284283