Progranulin and Central Nervous System Disorders / edited by Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura, Takayoshi Shimohata, Masugi Nishihara.

Format:

Book

Contributor:

Hara, Hideaki, editor.

Hosokawa, Masato, editor.

Nakamura, Shinsuke, Ph.D., editor.

Shimohata, Takayoshi, editor.

Nishihara, Masugi, 1954- editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Medical genetics.

Medicine.

Biochemistry.

Neurosciences.

Gene Function.

Molecular Medicine.

Protein Science.

Local Subjects:

Gene Function.

Molecular Medicine.

Protein Science.

Neurosciences.

Physical Description:

1 online resource (VII, 183 pages) : 37 illustrations, 13 illustrations in color

Edition:

First edition 2019.

Contained In:

Springer eBooks

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2019.

System Details:

text file PDF

Summary:

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Contents:

Chapter 1. Molecular and Functional Properties of Progranulin

Chapter 2. Progranulin as a biomarker for neurodegenerative diseases

Chapter 3. PGRN and FTLD

Chapter 4. PGRN and neurodegenerative diseases other than FTLD

Chapter 5. Progranulin Regulations of Lysosomal Homeostasis and its Involvement in Neurodegenerative Diseases

Chapter 6. Molecular and Functional Properties of Progranulin

Chapter 7. PGRN and neuroinflammation

Chapter 8. Neural Stem/Progenitor Cells and Progranulin

Chapter 9. Generation and phenotyping of progranulin-deficient mice

Chapter 10. Pleiotropic protective effects of progranulin in the treatment of ischemic stroke

Chapter 11. New therapeutic approaches against ocular diseases.

Other Format:

Printed edition:

ISBN:

978-981-13-6186-9

9789811361869

Access Restriction:

Restricted for use by site license.