Nanostructures for novel therapy : synthesis, characterization and applications / edited by Denisa Ficai, Alexandru Mihai Grumezescu.

Format:

Book

Author/Creator:

Ficai, Denisa, author.

Contributor:

Grumezescu, Alexandru Mihai, editor.

Ficai, Denisa, editor.

Series:

Micro & nano technologies.

Nanostructures in therapeutic medicine series

Micro and nano technologies

Language:

English

Subjects (All):

Nanostructures.

Physical Description:

1 online resource (908 pages) : color illustrations.

Edition:

1st edition

Place of Publication:

Boston, MA : Elsevier, [2017]

System Details:

text file

Summary:

Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy. The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability. Outlines how the characteristics of nanostructures made from different materials gives particular properties that can be successfully used in therapeutics Compares the properties of different nanostructures, allowing medicinal chemists and engineers to select which are most appropriate for their needs Highlights new uses of nanostructures within the therapeutic field, enabling the discovery of new, more effective drugs

Contents:

Cover

Title page

Copyright

Contents

List of Contributors

Foreword of the Series

Preface

About the Series (Volumes I-V)

About Volume I

Chapter 1 - Novel approaches for preparation of nanoparticles

1 - Introduction

1.1 - Evolution of Metal Nanoparticles in Pharmacy and Biotechnology

2 - Synthetic Methods for Preparation of Metal Nanoparticles

2.1 - Thermal Decomposition Method

2.2 - Sol-Gel Method

2.2.1 - Aqueous sol-gel method

2.2.2 - Nonaqueous sol-gel method

2.3 - Hydrothermal and Solvothermal Method

2.4 - Microwave-Assisted Method

2.5 - Polyol Method

2.6 - Sonochemical Method

2.7 - Liquid-Liquid Interface Method

2.8 - Phase-Transfer Method

2.9 - Biosynthesis Method

2.10 - Template-Directed Synthetic Method

3 - Application of Metal Nanoparticles in Theranostics

3.1 - Diagnosis and Drug Delivery

4 - Conclusions

Acknowledgments

References

Chapter 2 - Applications of nanoscale drugs carriers in the treatment of chronic diseases

1 - Introduction in Drug Delivery and Targeting

1.1 - Passive and Active Targeting

1.2 - Smart Drug Delivery Systems-Drug Carriers

1.3 - Microparticle Carriers

1.4 - Smart Stimuli Responsive Drug Delivery Systems

1.4.1 - pH

1.4.2 - Temperature

1.4.3 - Light

1.4.4 - Electrical field

1.4.5 - Magnetic field

1.4.6 - Ultrasounds

2 - Applications of Nanotechnology in Drug Delivery and Targeting

2.1 - Targeted Drug Delivery for Cancer Therapy

2.1.1 - Drug nanocarriers

2.1.1.1 - Gold nanoparticles

2.1.1.2 - Silver nanoparticles

2.1.1.3 - Magnetic nanoparticles

2.1.1.4 - Quantum dots

2.1.1.5 - Mesoporous silica nanoparticles

2.2 - Targeted Drug Delivery for Cardiovascular Diseases

2.3 - Targeted Drug Delivery for Diabetes

3 - Conclusions

References.

Chapter 3 - Functionalization of nanoparticles in specific targeting and mechanism release

2 - Controlled-Release Mechanisms

2.1 - Extended Release

2.2 - Stimuli-Responsive Release

2.2.1 - pH-responsive nanocarriers

2.2.2 - Redox-responsive nanocarriers

2.2.3 - Enzyme-responsive nanocarriers

2.2.4 - Thermoresponsive nanocarriers

2.2.5 - Photoresponsive nanocarriers

2.2.6 - Sonic and ultrasonic-responsive nanocarriers

2.2.7 - Other stimuli-responsive nanocarriers

3 - Project of Nanoparticles

3.1 - Size and Shape

3.2 - Surface Properties

4 - Nanoparticles Targeting

4.1 - Passive Targeting

4.2 - Active Targeting

4.2.1 - Aptamers

4.2.2 - Small molecules

4.2.3 - Peptides

4.2.4 - Antibodies and their fragments

4.2.5 - Carbohydrates and glycoproteins

5 - Conclusions

Chapter 4 - Fabrication and characterization of natural/synthesized, micro-, and nanostructured materials for biomedical applic...

2 - Pearl Shell

2.1 - Macro- and Microstructures

3 - Microstructure Analysis of Nacre by Transmission Electron Microscopy

4 - Micro-/Nanoparticles

5 - Surface Modification of Nanoparticles

5.1 - Shape Control: Iron Oxide Nanocubes

5.2 - Shape-Induced Self-Assembly of Nanocubes

6 - 2D Periodic Structure by Thermal Imprinting Process

7 - Functionalities for Biomedical Applications

7.1 - Thermal Coagulation Therapy

7.1.1 - Mechanism for the heat generation

7.1.2 - Ferrite materials for thermal coagulation therapy

7.1.3 - Heat generation ability for Y3Fe5O12

7.1.4 - Preparation of microspheres for embolization method

7.2 - Apatite Formation

7.2.1 - TEM observation of HAp formation on nacre

7.2.2 - Effect of heat treatment of nacre on the HAp formation in SBF

7.3 - Dissolution of Pearl Particles.

8 - Summary and Future Directions

Chapter 5 - Multifunctional nanostructured biopolymeric materials for therapeutic applications

2 - Biopolymers

2.1 - Natural Biopolymers: Polysaccharides and Proteins

2.1.1 - Chitosan

2.1.2 - Cellulose

2.1.3 - Collagen

2.1.4 - Alginate

2.2 - Biopolymers From Biotechnology

2.2.1 - Polyglycolide

2.2.2 - Polylactic acid

2.2.3 - Polylactide-co-glycolide

2.3 - Biopolymers From Microorganisms

2.3.1 - Polyhydroxyalkanoates

2.4 - Biopolymers From Petrochemical Sources

2.4.1 - Polycaprolactone

2.4.2 - Polyurethanes

3 - Multifunctional Nanostructured Materials

3.1 - Shape-Controlled Nanostructures

3.2 - Nanocomposites

3.3 - Nanostructured Surface

4 - Therapeutic Applications

4.1 - Targeted Delivery

4.2 - Cancer Therapy

4.3 - Tissue Engineering

4.3.1 - Selection of a stem cell type

4.3.2 - Selection of a biomaterial with specific properties

4.3.3 - Selection of an "in vivo" or "ex vivo" strategy for generating/regenerating the tissue/organ

5 - Conclusions and Perspectives

Chapter 6 - Polymeric pharmaceutical nanoparticles developed by electrospray

2 - Polymeric Particles and Atomizers

2.1 - Polymer Nanoparticles

2.2 - Preparation of Particles

2.3 - Atomization

2.4 - Electrospray Advantages and Disadvantages

3 - Electrospray

3.1 - History of Electrohydrodynamic Atomization (Electrospraying and Electrospinning)

3.2 - Principles and Theoretical Aspects

3.2.1 - Basic principles

3.2.2 - Scaling laws for the size

3.3 - Electrospray Modes

3.4 - EHDA Configurations

3.5 - Particle Production by EHDA

3.5.1 - Particle production by monoaxial EHDA

3.5.2 - Particle production by coaxial EHDA (CEHDA)

3.6 - Effective Parameters in electrospray.

4 - Therapeutic Nanoparticles Loaded by Electrospray

4.1 - Single Needle EHDA Processing

4.1.1 - Particles

4.1.2 - Aerosols

4.1.3 - Porous particles

4.2 - Two-Needle Coaxial Electrospray

4.2.1 - Capsules

4.2.2 - Bubble particles

4.2.3 - Porous particles

4.2.4 - Hollow particles

4.3 - Multicapillary Electrospray

Chapter 7 - Nanoformulation and administration of PUFA-rich systems for applications in modern healthcare

2 - Lipid Nanoparticles: Types and Fabrication Technology

2.1 - Nanoencapsulation

2.2 - Liposomes

2.3 - Nanocochleates

2.4 - Nanodispersions

2.5 - Micelles

2.6 - Nanoemulsions

2.7 - Multilayer Nanoemulsions

2.8 - Filled Hydrogel Particles

2.9 - Solid-Lipid Nanoparticles

2.10 - Nanostructured Lipid Carriers

3 - Understanding the Physiological System for Therapy: The Significance of Lipid Nanotechnology at Tissue and Cellular Level

3.1 - The Potential of Nanoparticles for Targeted Action at Tissue Level

3.1.1 - The gastrointestinal barrier

3.1.2 - The blood-brain barrier

3.2 - The Facets of Nanoparticle Play at Cellular Level

4 - Therapeutic Lipid Nanostructures

4.1 - For the Delivery of PUFAs

4.2 - Nanostructures for Cardiovascular Disease Treatment

4.3 - Nanostructures in Neurodegenerative Disease Treatment

4.4 - Nanostructures in Diabetes Management

4.5 - Nanostructures for Cancer Treatment

4.6 - Nanostructures for Infectious Diseases Treatment

4.7 - Nanostructures in Overcoming Proinflammatory Conditions

5 - Risk and Hazard Assessment

5.1 - Organic Solvents for Fabrication

5.2 - Potentially Hazardous Stabilizers and Surfactants

5.3 - Encapsulating Polymers

6 - Challenges and Scope

7 - Conclusions

Chapter 8 - Electrospinning and surface modification methods for functionalized cell scaffolds

1 - Electrospinning for Tissue Engineering

2 - Fundamentals of the Electrospinning Process

2.1 - Polymer Solution Parameters

2.1.1 - Polymer concentration

2.1.2 - Solvent volatility

2.1.3 - Solution conductivity

2.2 - Process Parameters

2.2.1 - Applied voltage

2.2.2 - Polymer flow rate

2.2.3 - Tip-collector distance

2.3 - Electrospun Fiber Materials

2.3.1 - Poly(glycolic acid) (PGA)

2.3.2 - Poly(lactic acid) (PLA)

2.3.3 - Poly(ε-caprolactone) (PCL)

2.3.4 - Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)

2.3.5 - Collagen

2.3.6 - Elastin

3 - Tuning the Morphology of Electrospun Scaffolds and its Effects on Cell Behavior

3.1 - Fiber Uniformity

3.2 - Fiber Diameter

3.3 - Fiber Orientation

3.4 - Pore Size of Electrospun Scaffold

4 - Surface Modification Methods of Electrospun Nanofibers

4.1 - Loading Biomolecules

4.1.1 - Physical surface adsorption

4.1.2 - Blend electrospinning

4.1.3 - Core-shell electrospinning

4.1.4 - Covalent immobilization of bioactive molecules

4.2 - Plasma Treatment

4.3 - Surface Graft Copolymerization

Chapter 9 - Short peptide self-assembled nanostructures for therapeutics innovative delivery

1.1 - The Advantages of Nanomaterials

1.2 - Self-Assembling Short Peptides as Nanomaterial Building Blocks

1.3 - Self-Assembling Short Peptides for Drug Delivery

2 - Preparation and Characterization of Self-Assembling Short Peptides

2.1 - Preparation of Short Peptides

2.2 - Characterization of Self-Assembling Short Peptides

3 - Drug-Delivery Applications

3.1 - Supramolecular Hydrogels as Systems for Drug Delivery.

3.2 - Physical Drug Entrapment in the Supramolecular Hydrogel Matrix.

Notes:

Includes bibliographical references and index.

Description based on print version record.

OCLC:

986525879