Structural Bioinformatics.

Format:

Book

Author/Creator:

Gu, Jenny.

Contributor:

Bourne, Philip E.

Language:

English

Subjects (All):

Computational Biology.

Molecular Biology.

Structural bioinformatics.

Local Subjects:

Computational Biology.

Molecular Biology.

Structural bioinformatics.

Physical Description:

1 online resource (2383 p.)

Edition:

2nd ed.

Place of Publication:

Wiley 2011

System Details:

text file

Summary:

Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing

Contents:

Cover; Title Page; Copyright; Foreword; Contributors; Section I DATA COLLECTION, ANALYSIS, AND VISUALIZATION; 1 DEFINING BIOINFORMATICS AND STRUCTURAL BIOINFORMATICS; WHAT IS BIOINFORMATICS?; TECHNICAL CHALLENGES WITHIN STRUCTURAL BIOINFORMATICS; INTEGRATING STRUCTURAL DATA WITH OTHER DATA SOURCES; REFERENCES; 2 FUNDAMENTALS OF PROTEIN STRUCTURE; THE IMPORTANCE OF PROTEIN STRUCTURE; THE PRIMARY STRUCTURE OF PROTEINS: THE AMINO ACID SEQUENCE; THE SECONDARY STRUCTURE OF PROTEINS: THE LOCAL THREE-DIMENSIONAL STRUCTURE; THE TERTIARY STRUCTURE OF PROTEINS: THE GLOBAL THREE-DIMENSIONAL STRUCTURE

THE QUATERNARY STRUCTURE OF PROTEINS: ASSOCIATIONS OF MULTIPLE POLYPEPTIDE CHAINSCONCLUSION; MORE INFORMATION ON THE INTERNET; REFERENCES; 3 FUNDAMENTALS OF DNA AND RNA STRUCTURE; INTRODUCTION; CHEMICAL STRUCTURE OF NUCLEIC ACIDS; BASE-PAIR GEOMETRY; CONFORMATION OF THE SUGAR PHOSPHATE BACKBONE; STRUCTURES OF NUCLEIC ACIDS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; 4 COMPUTATIONAL ASPECTS OF HIGH-THROUGHPUT CRYSTALLOGRAPHIC MACROMOLECULAR STRUCTURE DETERMINATION; INTRODUCTION; HIGH-THROUGHPUT STRUCTURE DETERMINATION; DATA ANALYSIS; HEAVY ATOM LOCATION AND COMPUTATION OF EXPERIMENTAL PHASES

DENSITY MODIFICATIONMOLECULAR REPLACEMENT; REFINEMENT; VALIDATION; CHALLENGES TO AUTOMATION; CONCLUSIONS; REFERENCES; 5 MACROMOLECULAR STRUCTURE DETERMINATION BY NMR SPECTROSCOPY; INTRODUCTION TO PROTEIN STRUCTURE DETERMINATION BY NMR; PREPARATION OF PROTEIN SAMPLES FOR NMR; PROTOCOL FOR PROTEIN STRUCTURE DETERMINATION BY NMR; PROBA BILISTIC APPROACHES AND AUTOMATION; DATABASES FOR BIOMOLECULAR NMR; ACKNOWLEDGMENTS; REFERENCES; 6 ELECTRON MICROSCOPY IN THE CONTEXT OF STRUCTURAL SYSTEMS BIOLOGY; INTRODUCTION; ELECTRON OPTICS AND IMAGE FORMATION; THREE-DIMENSIONAL RECONSTRUCTION

COMBINATION WITH OTHER APPROACHES: HYBRID METHODSFUTURE DIRECTIONS; ACKNOWLEDGMENTS; REFERENCES; 7 STUDY OF PROTEIN THREE-DIMENSIONAL STRUCTURE AND DYNAMICS USING PEPTIDE AMIDE HYDROGEN/ DEUTERIUM EXCHANGE MASS SPECTROMETRY (DXMS) AND CHEMICAL CROSS-LINKING WITH MASS SPECTROMETRY TO CONSTRAIN MOLECULAR MODELING; INTRODUCTION; OVERVIEW OF DXMS METHODOLOGY; EXAMPLES OF APPLICATIONS OF DXMS; DXMS ANALYSIS: CONCLUDING REMARKS; HYBRID BIOCHEMICAL/BIOINFORMATICS APPROACH TO LOWRESOLUTION STRUCTURE DETERMINATION USING CHEMICAL CROSS-LINKERS AND MASS SPECTROMETRY; RECENT APPLICATIONS

CONCLUSION WITH RESPECT TO CHEMICAL CROSS-LINKAGE METHODSACKNOWLEDGMENTS; REFERENCES; 8 SEARCH AND SAMPLING IN STRUCTURAL BIOINFORMATICS; INTRODUCTION; SAMPLING STRUCTURAL SPACE; SEARCH METHODS; DATA ANALYSIS AND REDUCTION; CONCLUDING REMARKS; ACKNOWLEDGMENTS; REFERENCES (Including Remarks on Recommended Further Reading); 9 MOLECULAR VISUALIZATION; INTRODUCTION; THE PROCESS OF MOLECULAR VISUALIZATION; MOLECULAR MODELS; MOLECULAR VISUALIZATION PROGRAMS; REFERENCES; Section II DATA REPRESENTATION AND DATABASES; 10 THE PDB FORMAT, mmCIF FORMATS, AND OTHER DATA FORMATS; INTRODUCTION

THE PDB FORMAT

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9781118210567

1118210565

OCLC:

778339075