Chiral photochemical scissors targeting proteins / Challa Vijaya Kumar, University of Connecticut, USA, Apinya Buranaprapuk, Srinakharinwirot University, Thailand.

Format:

Book

Author/Creator:

Kumar, Challa V. (Challa Vijaya), author.

Buranaprapuk, Apinya, author.

Contributor:

John G. Hartman Memorial Library Fund.

Language:

English

Subjects (All):

Photochemistry.

Photobiology.

Physical Description:

xvii, 428 pages ; 24 cm

Place of Publication:

Singapore ; Hackensack, NJ: World Scientific Publishing Co. Pte. Ltd., [2019]

Summary:

"The remarkable ability to target one or even a couple of sites on a large protein with a small molecule, under photochemical control, is a considerable challenge and this challenge has been addressed in some depth in this book. Systematic modification of the structure of the photoreagent provided valuable information on the binding site recognition as well as the mechanism of the photocleavage reaction"-- Provided by publisher.

Contents:

Introduction

Photophysical processes

Protein structure

Protein-ligand interactions

Binding thermodynamics

Photochemical protein scissors

Molecular architecture of protein photocleavage reagents

Photochemical scissors for BSA

Chiral recognition

Tuning the linker of the photoreagent

Protein scissors targeting lysozyme

Targeting biotin-binding sites on avidin with py-biotin

Inorganic photochemical proteases: Co(III)polyamine

Photocleavage of pepsin by Mo(VI) complexes

Photocleavage by uranyl ion

Computational modeling and docking studies

General methods for studying protein-ligand interaction and protein cleavage.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the John G. Hartman Memorial Library Fund.

ISBN:

9789813237612

9813237619

OCLC:

1052902222

Publisher Number:

99980808127